摘要
增生性玻璃体视网膜病变（proliferative vitreoretinopathy,PVR）是孔源性视网膜脱离手术常见的并发症,它是一种由多种细胞成分、玻璃体、细胞外基质以及大量自分泌或旁分泌的细胞因子的混合作用构成的复杂病理反应.胶质细胞、视网膜色素上皮细胞、视网膜色素上皮衍生细胞、成纤维细胞、成纤维细胞样细胞和巨噬细胞被认为在PVR产生的过程中起重要作用.较之PVR中固定成分和细胞组分,细胞因子如色素上皮细胞衍生因子、单核细胞趋化蛋白1、血管内皮生长因子、肿瘤坏死因子α及其受体和血小板衍生生长因子及其受体也不容忽视.PVR相关的细胞生物学和细胞因子机制仍需进一步阐明.在PVR形成之前进行临床干预将是防治本病的研究方向.5-氟尿嘧啶、低分子量肝素、柔红霉素、13顺式维甲酸等对PVR预防和治疗的临床有效性试验研究结果不尽相同.
Proliferative vitreoretinopathy （PVR） is a common complication of rhegmatogenous retinal detachment （RRD） surgery.PVR is caused by the complex pathologic reactions involving variety of cell componets,vitreous,extracellular matrix,and soluble autocrine or paracrine cell factors.Glial cells,retinal pigment epithelium（RPE） cells,RPE-derived cells,fibroblasts cells,fibroblast-like cells and macrophage cells are believed to assume an important roles in the etiology and progression of PVR.Compared with the cell components and extracellular matrix,the cell factors such as pigment epithelium derived factor （PEDF）,monocyte chemotactic protein-1 （MCP-1）,vascular endothelial growth factor （VEGF）,tumor necrosis factor-a（TNF-a）,tumor necrosis factor receptors （TNFRs）,platelet-derived growth factors （PDG-Fs） and platelet-derived growth factor receptor （PFGFR） are not neglectable.The relative cell biology and molecular machenisms with PVR are still elucidated.Clinical intervention before PVR developing are focusing as one of the promising avenues for the pervention and treatment of PVR.Clinical trials on the clinical efficacy of 5-fluorouracil （5-FU）,low-molecular-weight heparin （LMWH）,daunorubicin,and 13-cis-retinoic acid for PVR have yielded diverse results.
出处
《国际眼科纵览》
2013年第6期367-373,共7页
International Review of Ophthalmology
