眼眶成纤维细胞在甲状腺相关性眼病发病机制中的作用

The role of orbital fibroblasts in the pathogenesis of thyroid-associated ophthalmopathy

甲状腺相关性眼病的发病机制尚不十分明确.研究表明,此病发病过程中眼眶成纤维细胞既是自身免疫靶细胞,又是效应细胞,是其发病的关键因素.眼眶成纤维细胞自身抗体表达、氧化应激反应在甲状腺相关性眼病中起重要作用,通过对此方面的研究,探索对甲状腺相关性眼病有潜力的新的治疗方法.

Pathogenesis of thyroid associated ophthahnopathy （TAO） is still unclear.Studies showed that orbital fibroblasts were not only the target cells but also the effector in the autoimmune response of TAO.The orbital fibroblasts,through their autoantibodies expression and oxidative stress reaction,might play the important role during the occurrence and development of TAO.Based on the relative studies,the new potential pathway of clinical pharmacotherapy for TAO may be explored.