替莫唑胺化疗联合放疗治疗术后恶性脑胶质瘤的疗效评价

Efficacy of temozolomide chemotherapy combined with radiotherapy for postoperative brain malignant glioma

目的探讨恶性脑胶质瘤术后行放疗联合替莫唑胺化疗的疗效。方法选取52例恶性脑胶质瘤术后患者,随机分为两组,每组各26例。1组行放疗,每次2Gy,5次/周,共30次,总剂量60Gy。2组行放疗联合替莫唑胺化疗,除给予1组相同的放疗外,还接受替莫唑胺同期化疗,化疗完毕比较两组患者的整体疗效及生活质量。结果 2组完全缓解7例,部分缓解11例,有效率为69.23%;1组完全缓解4例,部分缓解6例,有效率占38.46%。两组疗效比较差异有统计学意义(P<0.01)。结论替莫唑胺联合放疗方案治疗术后恶性脑胶质瘤优于单纯放疗,值得临床推广。

Objective To explore the clinical effects of temozolomide chemotherapy combined with radiotherapy for postoperative brain malignant glioma. Methods Selected 52 cases of glioma, which randomly divided into radiation （group 1） and radiotherapy plus chemotherapy （group 2）, 26 patients in each group. Group 1 treated with postoperative three-dimensional conformal radiotherapy, 2 Gy each time, 5 times a week, a total of 30 times,60 Gy total dose. Giving group 2 the same radiation with group one, in addition, group 2 received temozolomide （TMZ） concurrent chemotherapy. Results There were 7 cases in group 2 completely eased. 11 cases were partial remission, the effective rate was 69.23%;only 4 cases were complete remission in group 1, 6 cases were partial remission, efficiency was 38.46%. Comparison of two groups, the difference was statistically significant （P＆lt;0.01）. Conclusion Temozolomide combined with radiotherapy has a better effect than simple radiation therapy on brain metastases, therefore, it is worth being generalized and applied in clinic.