溃疡性结肠炎灌肠液治疗溃疡性结肠炎的临床疗效观察

Observation on Clinical Curative Effect of Kuijie Enema in Treating Ulcerative Colitis

目的:观察中草药灌肠对溃疡性结肠炎的临床疗效。方法:将60例溃疡性结肠炎患者给予自拟灌肠液治疗,检测血清细胞因子水平白介素1β(Interleukin-1β,IL-1β)、肿瘤坏死因子(Tumor Necrosis Factor-α,TNF-α)、一氧化氮合酶-3(内皮型)(Nitric Oxide Synthase-3,Nos-3/eNos)的变化趋势以观察中草药液灌肠对溃疡性结肠炎的临床疗效。结果:治疗1个疗程后,总有效率达93.33%,IL-1β平均提升了19.7%,TNF-α平均降低了14.7%,Nos-3/eNos平均降低了20.8%。结论:溃疡性结肠炎灌肠液在防治溃疡性结肠炎方面,疗效可靠,使用方便,造价低廉,值得临床推广。

Objective： To observe the clinical curative effects of Chinese herbal medicine enema in treating ulcerative colitis. Methods： Sixty patients with ulcerative colitis were given the treatment of self-made enema. They were given the detection of serum cytokines,such as IL-1 β,TNF- α and Nos-3 / eNos to observe the clinical curative effects of the Chinese herbal medicine enema on ulcerative colitis. Results： After a course of treatment,the total effective rate was 93. 33%. The level of IL-1β was promoted by 19. 7% on average,and the level of TNF-α was reduced by an average of 14. 7%. The level of Nos-3 / e Nos was decreased by 20. 8%. Conclusion： In the treat- ment of UC,Chinese medicine Kuijie enema shows the advantages of reliable curative effect,easy application,and low cost,which is worth of clinical application.