摘要
目的：探讨肺炎支原体肺炎（MPP）患儿血清白介素6（IL-6）、白介素10（IL-10）、肿瘤坏死因子-α（TNF-α）和C-反应蛋白（CRP）的水平变化及临床意义。方法：选择MPP住院患儿72例，测定其急性期和恢复期血清IL-6、IL-10、TNF-α和CRP水平，并与对照组进行比较。结果：MPP患儿急性期血清IL-6、IL-10、TNF-α和CRP水平均高于恢复期和对照组，差异有统计学意义（P＜0.01）；恢复期与对照组间的差异均无统计学意义（P ＆gt;0.05）。急性期血清CRP水平与IL-6、IL-10、TNF-α呈正相关（P＜0.01）。结论：IL-6、IL-10、TNF-α和CRP参与小儿MPP的发病过程，动态监测血清IL-6、IL-10、TNF-α和 CRP的水平变化，有助于对MPP病情程度的判断与治疗效果的评价。
Objective：To investigate the changes of serum IL-6, IL-10, TNF-α and CRP in children with mycoplasma pneumoniae pneumonia （MPP） and its clinical significance. Methods：The serum levels of IL-6, IL-10, TNF-α and CRP in 72 children with MPP during acute stage and convalescence stage were detected respectively and compared with those in control group.Results：The serum levels of IL-6, IL-10, TNF-α and CRP of children with MPP in acute stage were significantly increased compared with those in convalescence stage and control group （P ＆lt; 0.01）, but no significant difference between convalescence stage and control group （P ＆gt; 0.05）. The serum levels of IL-6, IL-10 and TNF-α of children with MPP in acute stage were positively correlated with CRP （P＆lt;0.01）. Conclusions：IL-6, IL-10, TNF-α and CRP may be involved in the pathogenesis of MPP, and monitoring the changes of these cytokines can aid the judgment of disease and valuation of therapeutic efficacy of MPP.
出处
《医学检验与临床》
2013年第6期14-16,共3页
Medical Laboratory Science and Clinics
