心型脂肪酸结合蛋白对急性肺栓塞患者早期诊断及预后的价值

Early diagnosis and prognostic value of heart fatty acid binding protein in patients with acute pulmonary embolism

目的探讨心型脂肪酸结合蛋白对急性肺栓塞患者早期诊断及预后的价值。方法选取72例急性肺栓塞的患者作为研究组,同期门诊体检健康者30例作为对照组,比较两组及研究组治疗前后血浆心型脂肪酸结合蛋白(H-FABP)和B型脑钠肽前体(NT-proBNP)水平。结果研究组血浆H-FABP、NT-proBNP明显高于对照组(P<0.01)。治疗后研究组患者血浆H-FABP、NT-proBNP水平明显降低(P<0.05)。存活组治疗前血浆H-FABP、NT-proBNP明显低于死亡组(P<0.01)。结论急性肺栓塞患者血浆H-FABP浓度明显升高,检测血浆H-FABP有助于急性肺栓塞的早期诊断和预后判断。

Objective To investigate the diagnosis and prognostic value of heart fatty acid binding protein in patients with acute pulmonary embolism. Methods 72 patients with acute pulmonary embolism were selected as the study group, and 30 healthy people were taken as the control group. The levels of serum heart-type fatty acid binding protein （H-FABP） and type B pro-brain natriuretic peptide （NT-proBNP） were observed before and after the treat- ment. Results The levels of plasma H-FABP and NT-proBNP were significantly higher in the study group than in the control group （P 〈 0. 01 ）. After the treatment, the levels of plasma H-FABP and NT-proBNP decreased signifi- cantly （ P 〈 0. 05 ）. Left ventricular ejection fraction showed no significant difference （ P 〉 0. 05 ）. The levels of plas ma H-FABP and NT-proBNP were significantly lower in the survival group than in the death group （ P 〈 0. 01 ）. Con- clusion The level of H-FABP increases obviously in patients with acute pulmonary embolism, and the detection of H-FABP can be helpful for their early diagnosis and prognosis.