D-二聚体含量测定在脑出血患者中的应用

目的探讨D-二聚体(DD)含量测定在脑出血患者中的临床应用。方法选取收治的82例脑出血患者作为观察组,于入院时、伤后第4天和伤后第8天分别进行D-二聚体定量的检测,同期80例正常健康体检者作为对照组,比较两组检测结果的差异。结果观察组患者入院时DD水平为(0.713±0.023)μg/mL,显著高于对照组正常健康体检者的(0.215±0.031)μg/mL(P<0.05),此后逐渐下降,伤后第8 d为(0.420±0.013)μg/mL,较入院时下降明显(P<0.05)。结论脑出血患者发病早期伴有纤溶功能指标的显著变化,检测D-二聚体对评估脑出血伤情意义重大,值得临床广泛推广使用。

Objective To investigate the clinical application of D-dimer （DD） assay detection in patients with cerebral hemorrhage. Methods 82 cases of cerebral hemorrhage in our hospital were as the observation group. Quantitative D-dimer testing was conducted at the time of admission,the first four days after injury and eight days after injury. Over the same period 80 cases of normal healthy individuals were as the control group. The test results of two groups were compared. Results The DD levels of observation group were（0.713±0.023）μg/mL, which were significantly higher than（0.215±0.031）μg/mL of control group（P〈0.05）.The DD levels of observation group were significantly increased, then decreased gradually.DD levels of first eight days after injury were（0.420±0.013）μg/mL, which were significantly lower than admission（P〈0.05）. Conclusion Patients with cerebral hemorrhage have early indicators offibrinolysis changes. D-dimer testing for assessing cerebral hemorrhage injury is significant. It＇ s worthy of clinical widely used.