CD36基因多态性与急性冠脉综合征关联性的研究

Association between the single nucleotide polymorphisms of human CD36 gene and acute coronary syndrome

目的探讨新疆地区汉族、维吾尔（维）族人群CD36基因多态性与急性冠脉综合征（ACS）的关联性。方法采用聚合酶链反应一限制性片段长度多态性（PCR．RFLP）方法，对522例ACS患者和1215名健康体检者CD36基因单核苷酸多态性（sNP）进行基因型鉴定。结果在汉族和维族人群中，ACS组和对照组rsl722505的基因型及等位基因分布差异均有统计学意义（P值均〈0．05）。在汉族人群ACS组中rs17154181的A等位基因频率明显低于对照组（P=0．034）。logistic回归分析在调整混杂因素后，在汉族和维族人群中rsl722505的AA＋AG基因型者患ACS风险明显高于GG基因型者，汉族（OR=1．436，95％CI：1．047—1．970，P=0．025），维族（OR=1．589，95％CI：1．009～2．473，P=0．046）。汉族人群rsl7154181的AA＋AG基因型者患ACS风险明显低于GG基因型者（OR=0．667，95％CI：0．494—0．900，P=0．008）。结论CD36基因多态性在新疆地区汉族和维族人群间存在差异，且CD36基因可能与两族人群ACS的发生相关，rsl722505的AA＋AG基因型可能是汉族和维族人群ACS的危险因素，rsl8154181的AA＋AG基因型可能是汉族人群ACS的保护因素。

Objective The aim of the present study was to assess the association between the polymorphisms of CD36 gene and acute coronary syndrome （ACS）. Methods Genotypes of CD36 single nucleotide polymorphisms were detected under PCR-RFLP in 522 patients with ACS and 1 215 controls. Results For people under Han and Uygur ethnicities, the distribution of genotypes and allele of rs 1722505 was significantly different between ACS and the controls （all P〈 0.05）. For Han population, the frequency of A allele of rs17154181 was significantly lower in ACS group than that in the control group （P=0.034）. Results from logistic regression analysis showed that the AA ＋ AG genotype of rs 1722505 was significantly higher in ACS patients than that in controls both between the Hans and the Uygnrs （OR= 1.436,95%CI： 1.047-1.970, P=0.025 ; OR= 1.589,95%CI： 1.009-2.473, P=0.046, respectively）. For Hart people, AA＋ AG genotype of rs17154181 was significantly lower in ACS patients than that in controls （OR=0.667, 95% CI： 0.494-0.900, P=0.008）. Conclusion Data from the present study suggested that the CD36 gene might serve as a genetic marker of ACS in both Hart and Uygnr populations.