仿生功能生物界面材料

Functional Biointerface Materials Inspired from Nature

控制材料表面的化学和物理性质,进而对包括细胞及生物分子在内的生物个体在表面的行为进行操控是生物材料研究的一个重要任务。自然界中的生物系统表现出许多独特的性质,1)自然界中生物材料的优越性与表面的多尺寸微纳米结构有关;2)生物系统通常采用多重弱相互作用,如氢键作用、亲疏水效应等来解决生物分子相互作用的问题;3)自然界中的生物分子通常是手性分子并且偏好表现为某一特定的对称构型。总结了以这些特征而设计的带有独特功能的新型生物界面材料,重点阐述了纳米界面材料、智能生物界面材料和手性生物界面材料等。

It is one of the most important tasks to manipulate the interfacially chemical and physical properties, further to modulate the behaviors of cells and biomolecules on the material surfaces, which will largely promote high-performance biomaterials and devices. In this aspect,biological systems in nature give us lots of inspirations. The first one is that the superior attributes of natural biomaterials are closely related to the multi-scale micro- and nanostruetures on the surface; the second one is that biological system usually relies on highly specific weak interactions to modulate biomolecule interactions; the third one is that most of biomolecules in nature are chiral molecules and show high preference for one specific enantiomorphous configuration. These features bring many inspirations to construct novel biointerface materials such as structural biointerface materials,smart biointerface materials and chiral biointerface materials. This paper introduced recent progresses in these aspects,and prospective of these researches.