中华芦荟主要活性成分结合胆酸盐能力的研究

A Primary Study on Bile Salt Binding Capacity of Chinese Aloe and Its Major Functional Components

在体外模拟人体消化环境,以降血脂药物考来烯胺为对照,比较了经不同处理的中华芦荟与胆酸盐的结合能力,发现芦荟具有较强的结合胆酸盐的能力,其中黄酮类成分与胆酸盐的结合能力较强,且芦荟结合胆酸盐能力与黄酮类物质含量呈显著性正相关关系,而蒽醌类和多糖类物质的含量变化对芦荟结合胆酸盐的能力影响不显著。通过相关性分析初步判断了芦荟中结合胆酸盐的主要活性成分为黄酮类物质,且结合能力随黄酮的量呈正相关的关系。

The binding capacity of the Chinese aloe juices, freezed juice powder and the extracted flavonoids, polysaccharide and anthraquinone were compared under the simulated human digestive environment in vitro. The Chinese aloe juices, freezed juice powder and the extracted flavonoids were found to have strong ability to bind bile salts （sodium cholate, sodium taurocholate and sodium glycocholate）. Compared with polysaccharide and anthraquinone, flavonoids showed a significantly positive correlation with the bile salt binding capacity of Chinese aloe juices, indicating that flavonoids were the major functional components for the bile salt binding of Chinese aloe.