冠心病患者糖化血红蛋白与脂蛋白a的关系

Correlation between the level of glycosylated hemoglobin A1c and lipoprotein(a) in patients with coronary heart disease

目的探讨冠心病患者糖化血红蛋白（HbAlc）水平与脂蛋白a（LP－a）的关系。方法经冠脉造影确诊为冠心病患者316例，依据HbAlc水平将其分为正常组（HbAlc≤5．7％）、临界组（HbAlc5．7％～6．4％）、升高组（HbAlcI〉6．5％），比较三组间LP－a水平的差异。结果正常组、临界组、升高组LP－a随着HbAlc水平升高呈增高趋势，但差异无统计学意义（P〉0．05）。相关分析显示HbAlc与LP－a水平无相关性（P〉0．05）。结论冠心病患者HbAlc升高对LP－a水平无影响。

Objective To study the correlation between the level of glycosylated hemoglobin Alc （HbAlc） and lipopro- tein（a） （LP-a） in patients with coronary heart disease. Methods 316 patients with coronary heart disease diagnosed by coro- naryangiography were divided into the normal group （≤ 5.7%）, critical group （5.7%-6.4%）, elevated group （≥6.5%） accord- ing to the level of HbAlc and compared the difference of Lp-a among the there groups. Results LP-a of normal group, criti- cal group, elevated group showed a trend of mcreasing with elevated levels of HbAlc, but the difference was not statistically significant. Correlation analysis showed LP-a had no association with the level of HbAlc （P〉0.05）. Conclusion The level of LP-a is not influenced by the increasing level of HbAlc in patients with coronary heart disease.