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血小板内皮细胞黏附分子-1与肿瘤

Platelet-endothelial cell adhesion molecule-1 and tumor
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摘要 血小板内皮细胞黏附分子-1（PECAM-1）是免疫球蛋白超家族中的一种黏附分子,高表达于内皮细胞.近年来研究发现,PECAM-1与肿瘤的发生、血管生成、细胞凋亡以及耐药均相关,可能对肿瘤的诊断与治疗产生重要影响. Platelet-endothelial cell adhesion molecule-1 （PECAM-1） is a adhesion molecule of the immunoglobulin superfamily,which is highly expressed in endothelial cells.Recent studies show that PECAM-1 is related with tumorigenesis,angiogenesis,apoptosis and drug resistance,which may exert a significant influence on the diagnosis and treatment of tumor.
作者 刘芳 贾晓艳 王若雨
机构地区 大连大学附属中山医院肿瘤内科 大连大学附属新华医院病理科
出处 《国际肿瘤学杂志》 CAS 2014年第1期4-7,共4页 Journal of International Oncology
基金 国家自然科学基金（30970869）
关键词 抗原 CD31 肿瘤 新生血管化 病理性 细胞凋亡 抗药性 肿瘤 Antigens, CD31 Neoplasms Neovascularization, pathologic Apoptosis Drug resistance, neoplasm
分类号 R73-3 [医药卫生—肿瘤]
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参考文献18

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二级参考文献27

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国际肿瘤学杂志
2014年 第1期

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