低温等离子体在肿瘤治疗中的应用

Application of cold plasma in cancer therapy

研究表明,低温等离子体对肝癌、黑色素瘤、脑肿瘤、大肠癌、肺癌等具有一定的治疗作用.主要机制为：等离子体作用后使癌细胞内一氧化氮和活性氧水平增高,导致DNA损伤和线粒体功能障碍,细胞内线粒体凋亡通路被激活,改变了Bax/Bcl-2比例,活化凋亡蛋白caspase3、9,伴有细胞周期阻滞（G2-M期或S期）,最终导致细胞生长阻滞和细胞凋亡;增加β-catenin磷酸化,导致β-catenin降解,抑制整合蛋白2、4以及细胞表面局部黏着斑激酶的表达,破坏细细胞黏附,降低细胞的迁移和侵袭活性.

Research shows that cold plasma has therapeutic effect on hepatocellular carcinoma,melanoma,brain tumors,colorectal cancer,lung cancer and so on.The main mechanisms are as follows：the plasma can increase the levels of nitric oxide and reactive oxygen species in tumor cells,lead to DNA damage and mitochondrial dysfunction,activate mitochondrial apoptosis pathway,change the ratio Bax/Bcl-2,activate apoptosis proteins caspase3,9,accompanied by cell cycle arrest （G2-M phase or S phase）,eventually induce cell growth arrest and apoptosis; increase β-catenin phosphorylation,lead to β-catenin degradation,inhibit the expressions of integrin α2,integrin α4 and focal adhesion kinase on the cell surface,destroy cancer cells adhesion and reduce cell migration and invasion activities.