布比卡因脂质体研究进展

Progress of liposomal bupivacaine

背景布比卡因脂质体是一种新型的酰胺类局部麻醉药，是采用脂质体技术制备而成的缓释布比卡因。研究表明，布比卡因脂质体的局部镇痛作用时间可长达72h。目的拟对有关布比卡因脂质体的相关研究予以综述，重点介绍其在术后镇痛方面的相关研究进展。内容从布比卡因脂质体的特性、药动学、药效学及安全性4个方面综述布比卡因脂质体在术后镇痛中的应用。趋向布比卡因脂质体作为超长镇痛局麻药，在术后镇痛中将具有广泛的应用价值。

Background Liposomal bupivacaine is a kind of novel amide local anesthetics, and a slow-released bupivacaine produced by liposome technology. Many studies indicated that the analgesic time of liposomal bupivacaine could persist for 72 h. Objective To review the researches related to liposomal bupivacaine, especially the progress of liposomal bupivacaine for postsurgical analgesia. Content This review described the characteristics, pharrnacokinetics, pharmacodynamics and safety of liposomal bupivacaine for postsurgical analgesia. Trend As one of the local anesthetics producing uhralong-acting analgesia, the wide application of liposomal bupivacaine is quite promising in postsurgical analgesia.