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Th22细胞及IL-22在肿瘤中的作用 被引量：7

Effects of Th22 cells and IL-22 in tumors
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摘要 Th22细胞是新发现的一类CD4＋T辅助细胞亚群,以分泌白细胞介素（IL）-22,而不分泌IL-17和干扰素-γ（IFN-γ）为特点.已有研究显示,Th22细胞参与自身免疫性疾病、感染性疾病等的免疫过程.最近研究证实,Th22细胞及其细胞因子在多种肿瘤组织中分布和表达,但在肿瘤发生发展过程中是起抑制作用还是促进作用目前结论不一.关于Th22在肿瘤中的表达和作用机制的研究可以为肿瘤的特异性靶向治疗提供理论依据. Th22 cells,a new subset of CD4 ＋ T-helper cells,and is characterized by secreting interleukin （IL）-22 but not IL-17 or interferon （IFN）-γ.Research shows that Th22 cells participate in the immunologic processes of autoimmune diseases and infectious diseases.Recent studies confirm that Th22 cells and related cytokines distribute and express in a verity of tumor tissues,but the conclusions of their repressive or stimulative functions in tumorigenesis are different.The studies on Th22 cell expression in tumors and its underlying mechanism can provide a theoretical basis for specific targeted tumor therapy.
作者 刘国芳 向晓星
机构地区 扬州大学临床医学院
出处 《国际肿瘤学杂志》 CAS 2014年第2期93-96,共4页 Journal of International Oncology
关键词 肿瘤 TH22细胞 白细胞介素22 Neoplasms T helper 22 Interleukin-22
分类号 R730.2 [医药卫生—肿瘤]
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参考文献22

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同被引文献44

  • 1BinGao.Cytokines,STATs and Liver Disease[J].Cellular & Molecular Immunology,2005,2(2):92-100. 被引量：30
  • 2魏付桥,谢文彪.精氨酸及其衍生物NO对肿瘤的影响[J].医学综述,2007,13(9):683-685. 被引量：3
  • 3杨季云,张思仲,郭红,曾祥元,马布仁.肿瘤坏死因子α通过激活NF-κB信号通路加快肝细胞周期进程[J].生物化学与生物物理进展,2007,34(6):604-610. 被引量：35
  • 4Kuang DM,Peng C,Zhao Q,et al.Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells[J].Hepatology,2010,51 (1):154-164.
  • 5Trifari S,Kaplan CD,Tran EH,et al.Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T (H)-17,T (H) 1 and T (H) 2 cells[J].Nat Immunol,2009,10(8):864-871.
  • 6Duhen T,Geiger R,Jarrossay D,et al.Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells[J].Nat Immuno1,2009,10 (8):857-863.
  • 7Zhuang Y,Peng LS,Zhao YL,et al.Increased intratumoral IL-22-producing CD4 + T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival[J].Cancer Immunol Immunother,2012,61 (11):1965-1975.
  • 8Ling L,Zhao P,Yan G,et al.The frequency of Thl7 and Th22 cells in patients with colorectal cancer at pre-operation and post-operation[J].Immunol Invest,2015,44(1):56-69.
  • 9Liu T,Peng L,Yu P,et al.Increased circulating Th22 and Thl7 cells are associated with tumor progression and patient survival in human gastric cancer[J].J Clin Immunol,2012,32(6):1332-1339.
  • 10Zhang W,Chen Y,Wei H,et al.Antiapoptotic activity of autocrine interleukin-22 and therapeutic effects of interleukin-22-small interfering RNA on human lung cancer xenografts[J].Clin Cancer Res,2008,14(20):6432-6439.

引证文献7

二级引证文献12

国际肿瘤学杂志
2014年 第2期

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