还原型谷胱甘肽钠、磷酸肌酸钠治疗新生儿窒息后心肌损伤疗效观察

Observation on Reduced Glutathione and Creatine Phosphate Sodium in Treatment of Newborn's Myocardial Damage

目的观察还原型谷胱甘肽钠、磷酸肌酸钠治疗新生儿窒息后心肌损伤的疗效。方法将78例新生儿窒息致心肌损伤患儿随机分为还原型谷胱甘肽钠组、磷酸肌酸钠组和对照组。三组均给予常规治疗,还原型谷胱甘肽钠组静脉泵入还原型谷胱甘肽钠,磷酸肌酸钠组静脉泵入磷酸肌酸钠,对照组加用大剂量维生素C 250mg/kg。观察三组患儿治疗前、后症状、体征以及血清肌钙蛋白(cTnI)、肌酸激酶同工酶(CK-MB)的变化。结果还原型谷胱甘肽钠组、磷酸肌酸钠组和对照组治疗前cTnI、CK-MB比较,差异均无统计学意义,治疗后比较,还原型谷胱甘肽钠组和对照组、磷酸肌酸钠组和对照组差异均有统计学意义,还原型谷胱甘肽钠组和磷酸肌酸钠组差异无统计学意义;同组治疗前、后比较,差异均有统计学意义(P<0.05);还原型谷胱甘肽钠组、磷酸肌酸钠组的有效率分别为89.7%、84.6%,对照组有效率为60.9%,差异有统计学意义(P<0.05)。结论还原型谷胱甘肽钠、磷酸肌酸钠治疗新生儿窒息后心肌损伤疗效显著,可明显降低cTnI、CK-MB水平,从而改善心肌损伤。

Objective To observe clinical curative effect of Reduced Glutathione Sodium,Creatine Phosphate Sodium in treatment of myocardial damage after neonatal asphyxia.Methods 78 cases of newborn′s myocardial damage were randomly divided into the Reduced Glutathione Sodium group,Creatine Phosphate Sodium group and control group.The three groups were given normal treatments,the Reduced Glutathione Sodium group were given Reduced Glutathione Sodium through injection,Creatine Phosphate Sodium group were given Creatine Phosphate Sodium through injection,and control group were given large doses vitaminC 250mg/kg.Results Compared with the Reduced Glutathione Sodium group,Creatine Phosphate Sodium group and control group,CK-MB and cTnI before treament were not different,but after treament they were statisticaly significant different（P〈0.05）;The effective rate of the Reduced Glutathione Sodium group and Creatine Phosphate Sodium group was 89.7%and 84.6%,and of the control group 60.9%,the difference was statisticaly significant（P〈0.05）.Conclusion Reduced Glutathione sodium and Creatine Phosphate Sodium which can reduce the dose of CK-MB and cTnI have siginificant efffect in myocardial damage after neonatal asphyxia, thus they can improve myocardial damage.