莫沙必利联合埃索美拉唑治疗胃食管反流病的临床效果

Clinical effect of mosapride combined with esomeprazole in the treatment of gastroesophageal reflux disease

目的探讨莫沙必利联合埃索美拉唑治疗胃食管反流病的临床效果。方法选取本院2010年10月～2012年12月诊治的胃食管反流病患者92例，随机分为对照组与观察组，每组各46例。对照组患者采用埃索美拉唑治疗，观察组患者采用莫沙必利联合埃索美拉唑治疗。比较两组患者的临床病症改善情况、胃镜下食管炎愈合情况、不良反应情况。结果观察组临床病症改善的总有效率为95．6％、胃镜下食管炎的愈合率为100．0％，均明显高于对照组的82．6％、91．3％（P〈0．05）；观察组的不良反应发生率为13．0％，高于对照组的6．5％（P〈0．05）。结论莫沙必利联合埃索美拉唑可明显改善胃食管反流病患者的临床病症，提高治愈率，具有较高的安全性。

Objective To investigate clinical effect of mosapride combined with esomeprazole in the treatment of gastroesophageal reflux disease. Methods 92 patients with gastroesophageal reflux disease were selected in our hospital from October 2011 to December 2012 and were randomly divided into the observation group （n=46） and the control group （n=46）. 46 patients in the control group were treated with esomeprazole while patients in the observation group were treated with mosapride combined with esomeprazole.Clinical symptoms improvement,endoscopic esophagitis healing,adverse reactions were compared between the two groups. Results The total effective rate of clinical symptoms improvement （95.6%）,healing rate of endoscopic esophagitis （100.0%） in the observation group were significantly higher than that in the control group （82.6% and 91.3%） （P〈0.05）;incidence rate of adverse reactions （13.0%） in the obser- vation group was higher than that in the control group （6.5%） （P〈0.05）. Conclusion Mosapride combined with esomeprazole can significantly improve clinical symptoms of patients with gastroesophageal reflux disease,improve cure rate and has higher security.