蒙脱石散与消旋卡多曲辅助治疗婴幼儿轮状病毒性肠炎的效果观察

Curative effect observation of montmorillonite powder and racecadotril in treatment of infant rotavirus enteritis

目的分析研究蒙脱石散与消旋卡多曲辅助治疗婴幼儿轮状病毒性肠炎的临床效果及不良反应。方法本院2010年11月～2013年2月共收治轮状病毒性肠炎婴幼儿102例，将其随机分为A组和B组各51例，A组在常规治疗基础上给予消旋卡多曲进行辅助治疗，B组给予蒙脱石散进行辅助治疗，对比分析两组的治疗效果。结果A组总有效率为96．08％，B组总有效率为88．24％，差异无统计学意义（X^2=2．1702，P〉0．05）。A组的显效率为72．55％，显著高于B组的41．18％，差异有统计学意义（X^2=10．2320，P〈0．01）。A组退热、止泻、止吐、脱水纠正及住院时间均显著短于B组，差异有统计学意义（P〈0．01）。两组均无严重不良反应发生，且不良反应发生率差异无统计学意义（x。=0．3434，P〉0．05）。结论在常规治疗基础上，辅助蒙脱石散与消旋卡多曲治疗均可取得较好的效果，且消旋卡多曲可有效提高治疗显效率，缩短各项临床体征的消失时间，无明显不良反应，安全高效，值得临床推广应用。

Objective To analyze the curative effect and adverse reactions of montmorillonite powder and racecadotril in treatment of infant rotavirus enteritis.Methods 102 cases of infant rotavirus virus enteritis were treated in our hospital from November 2010 to February 2013,and were randomly divided into group A （51 cases） and group B （51 cases）. On the basis of conventional treatment,racecadotril was given to group A,montmorillonite powder was given to group B, therapeutic effect between two groups was comparatively analysed.Results The total effective rate was 96.08% in group A,was 88.24% in group B,with no significant difference （x^2=2.1702,P〉0.05）.The significant efficiency rate was 72.55% in group A,significantly higher than 41.18% in group B,with significant difference （x^2=10.2320,P〈0.01）.The time of relieving diarrhea,fever and stopping vomiting,correcting dehydration and length of hospital staying in group A was significantly shorter than that in group B,the difference was significant （P〈0.01）.The two groups had no serious adverse reactions,and the rate of adverse reactions had no significant difference （x^2=0.3434,P〉0.05）.Conclusion On the basis of conventional treatment,auxiliary treating with montmorillonite powder and racecadotril can achieve good effect,but racecadotril can effectively improve the treatment efficiency,and shorten the time of the disappearance of the Clinical signs,and has no obvious adverse reaction.So racecadotril is safe and effective,and should be applied in clinic.