血清胆碱酯酶作为一种新的急性时相反应蛋白的探讨

Discussion on serum cholinesterase as a new acute phase reaction protein

目的探究血清胆碱酯酶(ChE)在创伤、心肌梗死、感染、肿瘤等情况下活性的变化,分析血清ChE作为一种新的急性时相反应蛋白的可行性。方法选择抚顺市中心医院收治的重症感染病患者37例、外伤及手术患者56例、急性心肌梗死患者45例、恶性肿瘤患者43例以及健康体检人员50例,分别进行血清ChE的测定,并对检测结果进行统计学分析。结果各疾病组ChE活性均低于对照组,其中,手术组ChE活性下降最为显著,对照组与不同组间比较,差异均有统计学意义(P<0.01)。与治疗前比较,除了手术组患者治疗后的ChE活性下降外,其余各组患者的ChE活性均显著升高(P<0.01)。结论血清ChE具有急性时相反应蛋白的特性。

Objective To probe into the activity changes of serum cholinesterase （ChE） under the conditions of trauma, cardiac infarction,infection and tumor,and analyze the feasibility of serum ChE as a new acute phase reaction protein. Methods 37 cases of patients with serious infection,56 cases of patients with trauma,45 cases of patients with acute cardiac infarction,43 cases of patients with malignant tumor, and 50 cases of healthy participants recruited in our hospi- tal were selected.The serum ChE of all the study objectes were tested and the test results were statistically analyzed. Results The activity of serum ChE in each diseased group was lower than that of the control group,in which the activity of ChE in operation group decreased most remarkably.Compared with before the treatment,in addition to the operation group with ChE activity declined after the treatment,the ChE activity were significantly increased in rest of the groups （P〈0.01）. Conclusion The serum ChE has a feature of acute phase reaction protein.