摘要
目前临床上应用的抗HBV治疗药物主要有两类:干扰素和核苷(酸)类似物,前者不良反应较大,后者存在病毒耐药问题。抗HBV药物最大的问题是大多数患者在长期治疗后仍不能彻底清除病毒。因此,研发针对HBV不同靶位的新药对慢性HBV感染性疾病的治疗意义重大。本文就抗HBV药物靶位的研究进展进行综述。
The most commonly-used antiviral agents for HBV have been divided into two categories：interferons and nucleos（t）-ide analogues. The former has the limitation of multiple side effects, while the later is characterized by the problem of drug resis-tance. The major problem is that most patients cannot eradicate viruses through long-term antiviral therapies. Therefore, it is impor-tant to develop potent agents against various viral targets for the management of chronic HBV infectious diseases. This review focus-es on the recent progress in viral targets for anti-HBV agents.
出处
《传染病信息》
2013年第6期323-326,共4页
Infectious Disease Information
基金
国家"十二五"科技重大专项(2012ZX10004503)
国家自然科学基金面上项目(81171617)
关键词
乙型肝炎病毒
抗病毒药
治疗学
hepatitis B virus
antiviral agents
therapeutics
