高压氧联合创必复治疗深度褥疮的临床观察

Clinical effects of hyperbaric oxygen combined with Chuangbifu on deep bedsore

目的 探讨高压氧联合创必复（成纤维细胞生长因子生物蛋白海绵）治疗深度褥疮的临床疗效.方法 患者及家属知情同意,并经医院伦理委员会同意,将67例深度褥疮患者按治疗方法不同分为对照组16例、创必复组16例、高压氧组15例和高压氧联合创必复组（高压氧联合组）20例,观察并比较各组患者深度褥疮愈合情况和护理时间.结果 在相同观察时间内患者治愈率比较,创必复组（62.5％）、高压氧组（46.7％）和高压氧联合组（80.0％）均优于对照组（31.2％）,差异有统计学意义（P＜0.01）,高压氧联合组优于创必复组、高压氧组（P＜0.05）;护理时间比较,高压氧组、创必复组、高压氧联合组间接护理时间均较对照组明显缩短（P＜0.01）,高压氧联合组间接护理时间较创必复组、高压氧组明显缩短（P＜0.05）.结论 高压氧联合创必复治疗深度褥疮明显提高了疗效,降低了医院护理工作量.

Objective To investigate the clinical effects of hyperbaric oxygen （HBO） combined with Chuangbifu （an FGF biologic protein sponge dressing） on deep bedsore.Methods A total of 67 patients were randomly divided into 4 groups：the control group （n =16）,the Chuangbifu group （n =16）,the HBO group （n =15） and the HBO combined with Chuangbifu group （n =20）.Then,healing progress and nursing time were observed and compared between the 4 groups.Results Cure rates of the Chuangbifu group（62%）,the HBO group（46.7%）and the HBO combined with Chuangbifu group（80%）in the same observation periods were all superior to those of the control group （P 〈 0.01）,and statistical significance could be seen between them （P 〈 0.05）.Cure rate of the HBO combined with Chuangbifu group was superior to those of the Chuangbifu groupand the HBO group （P 〈 0.05）.With regard to nursing time in the four groups,the nursing time for the HBOgroup,the Chuangbifu group and the HBO combined with Chuangbifu group was all significantly shorter than thatof the control group （P 〈 0.01）,and indirect nursing time for the HBO combined with Chuangbifu group wassignificantly shorter than that of the Chuangbifu group and the HBO group （P 〈 0.05）.Conclusions HBOtherapy combined with Chuangbifu could significantly increase the therapeutic effect on patients with deepbedsore,and at the same time,it could decrease nursing load on the medical personnel.