原发性肝细胞肝癌患者血清CTGF测定的临床意义

Clinical significance of serum CTGF in patients with hepatocellular cellular carcinoma

目的:探讨原发性肝细胞肝癌(hepatocellular carcinoma,HCC)患者血清结缔组织生长因子(connective tissue growth factor,CTGF)水平的变化及临床意义。方法:采用酶联免疫吸附法检测384例HCC患者、126例慢性肝病患者及102名健康对照者的血清CTGF水平,并分析血清CTGF水平与HCC的TNM分期、肿瘤直径、AFP分级间的关系。结果:HCC患者的血清CTGF水平明显高于正常对照者(P<0.001),亦高于慢性肝病患者(P<0.005)。同时,HCC患者的血清CTGF水平随其TNM分期增加而明显升高(P=0.018),且与AFP分级呈正相关(P=0.028)。结论:CTGF可能是HCC的一个潜在的促肿瘤形成因子。血清CTGF水平变化与HCC的发生、发展有关,其测定有助于了解HCC的发生机制和患者的预后评估。

Objective： To investigate the change of level of serum connective tissue growth factor （CTGF） in patients with hepatocellular cellular carcinoma （HCC） and its clinical significance. Methods： Enzyme linked immunosorbent assay （ELISA） was used to detect serum CTGF level in 384 patients with HCC, 126 patients with chronic liver disease （CLD） and 102 healthy controls. Results： The level of serum CTGF in HCC group was significantly higher than that in normal controls and CLD group. In patients with HCC, serum CTGF increased significantly with the increase of TNM stage and was positively correlated with AFP grading. Conclusions： CTGF may be a potential promoting factor for the genesis of HCC. The change of serum CTGF is correlated with the development and progression of HCC, and its determination might contribute to the understanding of genesis of HCC and the prognostic evaluation.