由结合疫苗产品历史沿革带来的思考

Some reflections from the history of conjugate vaccine development

由于优异安全性和有效性数据,结合疫苗已成为细菌性疫苗研制的一个方向,但因不同团体独立研发,产生了不同的结合技术,也带来了一些困惑。通过对几个具有代表性的结合疫苗研发团队的研究历程的回顾,探讨了结合方法、载体蛋白质、剂型等热点话题,以期对结合疫苗的研制有所帮助。

Due to the excellent safety and efficacy data, conjugate vaccine has become a direction for bacterial vaccine de- velopment. , but different conjugate technologies from different independent research groups also brought some confusion. After reviewing the research history of some representative team, conjugate methods, carrier protein, vaccine formulation and other hot topics were discussed.