急性颅脑损伤患者血清及脑脊液中炎性因子的变化及临床意义

Changes in proinflammatory cytokines in serum and cerebrospinal fluid and their clinical significance in patients with traumatic brain injury

目的探讨炎症细胞因子IL-lβ,IL-6与颅脑损伤程度的关系及临床意义。方法对近年来我院收治的780例急性颅脑损伤患者按损伤程度分组(轻、中、重及特重型组),检测血清及脑脊液中IL-1β及IL-6水平,并对比了不同程度急性颅脑损伤患者上述因子水平的差异并分析其临床意义。结果轻型、中型、重型及特重型颅脑损伤患者血清及脑脊液IL-1β及IL-6水平均显著增加,而重型和特重型颅脑损伤患者两种因子水平要显著高于其他患者,死亡患者IL-1β及IL-6水平高于其他所有患者。结论血清及脑脊液中IL-1β及IL-6水平与颅脑损伤的程度密切相关,能够作为临床监测指标。

Objective To investigate the relationship of interleukin （IL） -1βand IL-6 levels with the severity of traumatic brain injury （TBI） and their clinical significance. Methods A total of 780 patients with TBI, who were admitted to our hospital from April 2009 to April 2013, were divided into mild, moderate, severe, and highly severe groups. The levels of IL-1β and IL-6 in serum and cerebro- spinal fluid （CSF） were measured. The IL-1β and IL-6 levels were compared between these groups, and their clinical significance was analyzed. Results IL-1β and IL-6 levels were significantly increased in the mild, moderate, severe, and highly severe groups. The se- vere and highly severe groups had significantly higher IL-1β and IL-6 levels than the other two groups, while the patients who died had higher IL-1β and IL-6 levels than other patients. Conclusions The levels of IL-1β and IL-6 in serum and CSF are closely related to the severity of TBI and can be used as clinical monitoring indices.