宿主抗曲霉菌感染免疫机制的研究进展

Research progress of host's immune mechanism to resist Aspergillus infection

随着广谱抗生素、糖皮质激素和免疫抑制剂的广泛应用,艾滋病、糖尿病等疾病的发病率不断上升,免疫受损患者日益增多,侵袭性曲霉菌感染逐渐增加,并越来越受到关注。阐明曲霉菌感染的发病机制,从而找到有效的治疗手段是基础研究和临床工作者的共同命题。宿主的免疫对于曲霉菌感染的发病机制具有至关重要的作用,掌握宿主对曲霉菌的免疫机制是研究曲霉菌感染的基础,该文就宿主对曲霉菌感染免疫机制的研究进展作一综述。

With the wide use of broad-spectrum antibiotics,corticosteroids and immunosuppressive drugs,and the rising incidence of AIDS,diabetes etc,the number of immunocompromised patient is increasing.Follow this,invasive Aspergillus infections are increasing gradually and more attentive than before.To clarify the pathogenesis and find the effective treatment of Aspergillus infections are the common propositions for basic researches and clinical workers.Host＇s immunity plays an important role in the pathogenesis of Aspergillus infection.To master host＇s immune mechanisms of Aspergillus is the foundation of studying Aspergillus infection.In our article,progresses on the study of host＇s immune mechanisms against Aspergillus infections are reviewed.