曲美他嗪对稳定型心绞痛患者疗效及对运动耐量的影响

Effect of trimetazidine on curative effect and exercise tolerance in patients with stable angina cordis

目的：探讨曲美他嗪对稳定型心绞痛患者疗效及对运动耐量的影响。方法回顾性分析我院2011～2013年心内科收治的300例稳定性心绞痛患者的资料，按照患者治疗方式分为观察组及对照组，各150例，两组患者均给予β受体阻滞剂、阿司匹林、氯吡格雷、钙通道拮抗剂、他汀类常规药物治疗，观察组加用曲美他嗪片，连续治疗2周，对患者进行运动耐量测定，对两组患者治疗后临床症状及运动耐量进行评价。结果观察组患者临床总有效率高，与对照组患者比较差异有统计学意义（P＜0.05）；观察组患者运动耐量观察指标改善明显，与对照组患者比较差异有统计学意义（P＜0.05）。结论曲美他嗪能改善心绞痛患者心肌能量代谢，减少患者心绞痛发作，提高运动耐量，效果满意。

Objective To investigate the effect of trimetazidine on curative effect and exercise tolerance in patients with stable angina cordis. Methods The information of 300 patients with stable angina cordis from 2011 to 2013 in the cardiology department of our hospital were retrospectively analyzed. All patients were divided into the observation group and the control group according to the different treatment methods, and each group had 150 cases. The patients of the two groups were both given the conventional drugs treatment, such as beta-blockers, aspirin, clopidogrel, calcium channel blockers, statins, while the patients of the observation group were added with trimetazidine treatment for 2 weeks, and the exercise tolerance of patients were measured. The clinical symptoms and exercise tolerance of patients in the two groups were evaluated after the treatment. Results The clinical total effective rate of the observation group was higher than that of the control group, the difference was statistically significant（P〈0.05）.The exercise tolerance of the observation group improved more significantly compared with the control group, the difference was statistically significant（P 〈 0.05）. Conclusion Trimetazidine can improve the myocardial energy metabolism in patients with angina cordis, reduce the onset of angina cordis, improve the exercise tolerance, and has satisfactory effect.