纳洛酮对急性酒精中毒的治疗效果及安全性

The efficacy and safety of naloxone on treatment of acute alcoholism

目的：探讨纳洛酮治疗急性酒精中毒的临床疗效与安全性。方法选取我院2011年6月～2013年6月收治的62例酒精中毒患者作为研究对象，包括18例兴奋期患者，36例处于共济失调期，8例患者处于昏迷期，全部行纳洛酮药物治疗。结果兴奋期患者与共济失调期患者行药物治疗后一般在3h内清醒，大部分陷入昏迷的患者行药物重复治疗后12h内苏醒；兴奋期患者与共济失调患者使用纳洛酮药物的剂量约为0.4～1.2mg，昏迷患者纳洛酮药物剂量为1.2～2.0mg，且需要重复给药。结论对急性酒精中毒患者行纳洛酮药物治疗能够加快患者清醒，效果明显，对于保障患者的生命安全作用突出。

Objective To explore the efficacy and safety of naloxone on treatment of acute alcoholism. Methods 62 patients with alcoholism admitted and treated in our hospital from Jun 2011 to Jun 2013 were selected as research objects, including 18 patients in the stage of excitement, 36 patients in the stage of ataxia and 8 patients in the stage of coma. All the patients were treated with naloxone. Results Patients in the stage of excitement or ataxia generally became sober within 3 hours after drug therapy. Most patients in coma became sober within 12 hours after repeated drug therapy. The dosage of naloxone for patients in the stage of excitement or ataxia was 0.4-1.2mg. The dosage for patients in coma was 1.2-2.0mg with repeated drug administration. Conclusion Naloxone demonstrates good efficacy on treatment of patients with acute alcoholism. It can accelerate sobriety and protect life safety of patients.