血必净对急性胰腺炎患者血清TNF-α、IL-1β和IL-6浓度的影响

目的探讨血必净对急性胰腺炎患者血清TNF-α、IL-1β和IL-6浓度的影响。方法将79例急性胰腺患者随机分为血必净治疗组(41例)和常规治疗组(38例),另用健康体检者33例作为对照组。分别于发病后第1、3天和第1、2周抽血,采用酶联免疫吸附法(ELISA)测定血清TNF-α、IL-1β和IL-6的浓度。结果发病后第1、3天,患者血清TNF-α、IL-1β和IL-6浓度高于对照组,发病后第1周患者血清TNF-α、IL-1β浓度高于对照组。与常规治疗组相比,血必净治疗组第3天、第1周血清TNF-α、IL-1β浓度降低,第3天血清IL-6浓度降低。结论在急性胰腺炎发病后早期,血必净治疗能够降低患者血清TNF-α、IL-1β和IL-6的浓度,保护胰腺及其他器官。

Objective To invesgate the effects of Xuebijing on serum concentrations of TNF-α,IL-1β and IL-6 in patients with acute pancreatitis（AP）.Methods All of 79 patients were randomly divided into two groups：Xuebijing group （41 cases） and conventional treatment group （55 cases）, with 33 healthy volunteers as a control group. ELISA were applied to measure the serum concentration of these cytokine：TNF-α, IL-1β and IL-6 at different timepoints（1 d,3 d,1 w,2 w after the onset of AP ）. Results The serum of concentrations of TNF-α, IL-1β and IL-6 reached the maximum on the first day when AP occured, the serum concentration of TNF-α,IL-1βand were still at high level at the third day after occurrence compared with the control group（P〈0.05）. And at the end of the first week, serum concentration of TNF-α,IL-1βwere still higher than the control group（P〈0.05）. Compared with the conventional treatment group, serum concentrations of TNF-αof Xuebijing group were significantly decreased from the third day to the seventh day, and the serum concentrations of IL-1βand IL-6 were significantly reduced on the third day （P〈0.05）. Conclusion Xuebijing can reduce serum concentrations of TNF-α, IL-1βand IL-6 at the early stage of the AP course. Inhibiting the inflammation may be the molecular mechanisms through which Xuebijing treat AP.