冠心病与雄性激素的相关性

Correlation of coronary heart diseases with endogenous androgen level

目的 探讨老年男性冠心病与内生性血浆睾酮及其它相关因素的关系.方法 选择ACS男性患者28例、稳定型心绞痛（SAP）男性患者28例、男性健康体检者28例为对照组.分别对三组人员进行颈动脉多普勒检查,并检查外周血睾酮（T）浓度及血脂（TC、LDL-C）、血糖（Glu）、CRP等相关指标,计算BMI.结果 ACS组、SAP组外周血T、TC、LDL-C、Glu等均显著高于对照组（P＜0.05）,冠心病患者（包括ACS、SAP）较对照组颈动脉中内膜厚度（IMT）、斑块个数等差异有统计学意义（P＜0.05）.ACS组与SAP组比较：外周血T、Tc、LDL-C、CRP的浓度及BMI、IMT、不稳定斑块差异均有统计学意义（P＜0.05）.ACS组与SAP组比较外周血Glu及硬斑例数差异无统计学意义（P＞0.05）.结论 老年男性冠心病患者T浓度与动脉粥样硬化、不稳定斑块、Tc、LDL-C、BMI呈负相关.

Objective To investigate the relationship between elderly male patients with coronary heart diseases （CHD） and endogenous androgen level and other related factors.Methods 28 male patients with acute coronary syndrome （ACS） were chosen as research group,28 male patients with stable angina pectoris （SAP） were chosen as observation group,and 28 healthy male people were selected as control group.All of three groups were checked by carotid artery Doppler ultrasonography and the peripheral blood concentration of testosterone （T）,TC,LDL-C,Glu,CRP were measured,BMI was calculated in all three groups.Results Peripheral blood concentration of T,TC,LDL-C,Glu in ACS group and SAP group were significantly higher than those of the control group（P 〈0.05）.IMT and number,quality of plaque in patients with ACS and SAP were significantly different compared with the control group （P 〈 0.05）.T,Tc,LDL-C,CRP,BMI,IMT,unstable plaque were significantly different between ACS group and SAP group（P 〈 0.05）.Glu had no statistical difference between ACS group and SAP group （P 〉 0.05）.Conclusion Peripheral blood concentration of T was negatively correlated with arterosclerosis,unstable plaque,Tc,LDL-C,BMI in old male CHD patients