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儿童自身免疫性甲状腺炎患者血清趋化因子CXCL10及其受体CXCR3的变化及其临床意义 被引量：3

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摘要 目的 探讨血清趋化因子CXCL10及其受体CXCR3在儿童自身免疫性甲状腺炎（HT）患者中的水平变化及其临床意义.方法 采用ELISA检测42例儿童自身免疫性甲状腺炎患者血清CXCL10和CXCR3水平,并以42例健康体检儿童作为对照.结果 HT组患者血清CXCL10和CXCR3水平明显高于对照组（t=15.509、23.751,均P＜0.05）,且血清CXCL10和CXCR3水平在儿童HT发病初期及未缓解期高于缓解期（t=17.188、20.048、16.427、20.369,均P＜0.05）；血清CXCL10与CXCR3表达呈高度正相关（r=0.772,P＜0.01）.结论 CXCL10和CXCR3在儿童自身免疫性甲状腺炎的过度表达可能与其发生和发展有关,在儿童HT病程中存在着动态变化,可以作为预测儿章HT的疾病活动性的指标之一.
作者 吴联专 陈宠 郑贤干 夏苗苗 李蓓蓓 李来亮
机构地区 浙江省苍南县第三人民医院检验科 浙江省苍南县第三人民医院内科 浙江省苍南县第三人民医院超声科
出处 《中国基层医药》 CAS 2014年第2期259-261,共3页 Chinese Journal of Primary Medicine and Pharmacy
关键词 自身免疫性甲状腺炎 超化因子
分类号 R581.4 [医药卫生—内分泌]
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参考文献7

  • 1胡天一,刘戈力,杨箐岩,马咸成,刘国玉.趋化因子CXCL10在儿童自身免疫性甲状腺炎中的作用和变化[J].天津医科大学学报,2010,16(1):117-119. 被引量：2
  • 2Liu C, Papewalis C, Domberg J, et al. Chemokines and autoimmune thyroid diseases[J]. Horm Metab Res,2008,40(6) :361-368.
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二级参考文献9

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中国基层医药
2014年 第2期

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