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构建移植后复发防治的综合体系 被引量：3

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摘要 异基因造血干细胞移植（allo-HSCT）是血液恶性肿瘤有效乃至唯一根治方法。国际骨髓移植登记组（CIBMTR）的资料显示，复发主要发生在移植后4～18个月，在非血缘和同胞相合移植后的死因中占33％和47％，位列移植失败的首要原因[1]。
作者 黄晓军
机构地区 北京大学人民医院北京大学血液病研究所造血干细胞移植北京市重点实验室
出处 《中华内科杂志》 CAS CSCD 北大核心 2014年第2期81-83,共3页 Chinese Journal of Internal Medicine
基金 国家自然科学基金（81230013） 北京市自然科学基金（7122193）
关键词 复发防治 移植后 异基因造血干细胞移植 血液恶性肿瘤 根治方法 骨髓移植 非血缘
分类号 R457.7 [医药卫生—治疗学]
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参考文献15

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  • 2Schmid C,Labopin M,Nagler A. Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia:a retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party[J].{H}Journal of Clinical Oncology,2007.4938-4945.
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同被引文献48

  • 1刘启发,徐丹,张钰,魏永强,孙竞,宋兰林,刘晓力,孟凡义,周淑芸.异基因造血干细胞移植后移植物抗白血病效应与移植物抗宿主病关系的临床观察[J].中华血液学杂志,2005,26(2):120-121. 被引量：4
  • 2姚利,陈子兴,岑建农,何军,邱桥成,鲍晓晶,袁晓妮.实时定量逆转录PCR在白血病标志物检测中的应用[J].临床检验杂志,2007,25(3):212-214. 被引量：1
  • 3王昱,刘开彦,许兰平,刘代红,陈欢,韩伟,陈育红,石红霞,张耀臣,王景枝,张晓辉,陈瑶,黄晓军,陆道培.异基因造血干细胞移植治疗高危恶性血液病[J].中华内科杂志,2007,46(11):903-906. 被引量：16
  • 4Pasqulni M, Wang Z, Horowitz MM, et al. 2013 report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders [ J ]. Clin Transpl, 2013: 187-197.
  • 5Ditschkowski M, Halerdach C, Schuhe C, et al. Occurrence of AML in cells of donor origin after treatment of CML in relapse with imatinib and donor stem cell boost 16 years after the original allogeneic BMT [ J ]. Bone Marrow Transplant, 2009, 44 ( 4 ) : 265-266.
  • 6van den Brink MR, Porter DL, Giralt S, et al.Relapse after allogeneic hematopoietic cell therapy [ J ]. Biol Blood Marrow Transplant, 2010, 16 ( 1 Suppl ) :S138-S145.
  • 7Rowe JM, Guek G, Burnett AK, et al. Induction therapy for adults with aeute lymphoblastic leukemia: results of more than 1 500 patients from the international ALL trial: MRC UKALL )/ECOG E2993 [ J ]. Blood,2005, 106 ( 12 ) : 3760-3767.
  • 8Ringden O, Iabopin M, Gluckman E, et al. Graft-versus-leukemia effect in allogeneic marrow transplant recipients with acute leukemia is maintained using cyclosporin A combined with methotrexate as prophylaxis. Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation [ J ]. Bone Marrow Transplant, 1996, 18 ( 5 ) : 921-929.
  • 9Remberger M, Kumlien G, Aschan J, et al. Risk factors for moderate-to-severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation [ J ]. Biol Blood Marrow Transplant,2002, 8 ( 12 ) : 674-682.
  • 10Baron F, Labopin M, Niederwieser D, et al. Impact of graft-versus- host disease after reduced- intensity conditioning allogeneic stem celltransplantation for acute myeloid leukemia:a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation [ J ] Leukemia, 2012, 26 (12): 2462-2468.

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中华内科杂志
2014年 第2期

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