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Xp11．2易位／TFE3基因融合相关性肾癌15例分析 被引量：19

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摘要 Xp11．2易位／TFE3基因融合相关性肾癌（简称Xpll．2肾细胞癌）是WHO肾细胞癌病理组织学分类中的独立亚型”[1]，其命名来源于肿瘤均涉及Xpll．2断点的几种不同的染色体易位，形成TFE3融合基因，导致肿瘤细胞中TFE3蛋白的过度表达，并以此成为Xpll．2肾细胞癌的诊断标准”[2]。
作者 甘卫东 杨荣 屈峰 徐林锋 李笑弓 张古田 郭宏骞 贾瑞鹏
机构地区 南京大学医学院附属鼓楼医院泌尿外科 南京医科大学附属南京医院泌尿外科
出处 《中华外科杂志》 CAS CSCD 北大核心 2014年第2期153-154,共2页 Chinese Journal of Surgery
关键词 染色体易位 基因融合 相关性 肾癌 肾细胞癌 肿瘤细胞 病理组织 融合基因
分类号 R737.11 [医药卫生—肿瘤]
  • 相关文献

参考文献11

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  • 2Argani P,Lal P,Hutchinson B. Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions:a sensitive and specific immunohistochemical assay[J].{H}American Journal of Surgical Pathology,2003,(6):750-761.
  • 3Kuroda N,Mikami S,Pan CC. Review of renal carcinoma associated with Xp1 1.2 translocations/TFE3 gene fusions with focus on pathobiological aspect[J].{H}Histology and Histopathology,2012,(2):133-140.
  • 4薛彦诗,甘卫东,刘铁石,张士伟,姚林方,连惠波,张古田,李笑弓,郭宏骞.Xp11.2易位/TFE3基因融合相关性肾癌的临床与病理分析[J].江苏医药,2012,38(5):537-540. 被引量：7
  • 5Green WM,Yonescu R,Morsberger L. Utilization of a TFE3 Break-apart FISH Assay in a Renal Tumor Consultation Service[J].{H}American Journal of Surgical Pathology,2013,(8):1150-1163.
  • 6徐晓晨,甘卫东,李笑弓,张古田,刘铁石,姚林方,屈峰,连惠波,张士伟,燕翔,郭宏骞.Xp11.2易位/TFE3基因融合相关性肾癌与肾透明细胞癌的螺旋CT诊断鉴别[J].现代泌尿外科杂志,2012,17(2):122-124. 被引量：42
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二级参考文献20

  • 1Eble JN,Sauter G,Epstein J,et al.Pathology and genetics oftumors of the urinary system and male genital organs[M].Lyon,France:IARC,2004:37-38.
  • 2Argani P,Antonescu CR,Illei PB,et al.Primary renal neo-plasms with the ASPL-TFE3gene fusion of alveolar soft partsarcoma:a distinctive tumor entity previously included amongrenal cell carcinomas of children and adolescents[J].Am JPathol,2001,159(1):179-192.
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  • 8Hong SB,Oh HB,Valera VA,et al.Inactivation of the FLCN tumor suppressor gene induces TFE3transcriptional activity by increasing its nuclear localization[J].PLoS One,2010,5(12):157-193.
  • 9Argani P,Lal P,Hutchinson B,et al.Aberrant nuclear immu-noreactivity for TFE3in neoplasms with TFE3gene fusions:a sensitive and specific immunohistochemical assay[J].Am J Surg Pathol,2003,27(6):750-761.
  • 10Martignoni G,Pea M,Gobbo S,et al.Cathepsin-K immunore-activity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomas[J].Modern Patho-logy,2009,22(8):1016-1022.

共引文献43

同被引文献198

  • 1姜锦贵,印洪林,周晓军.儿童肾细胞癌3例报告及文献复习[J].江苏大学学报（医学版）,2005,15(1):89-90. 被引量：1
  • 2饶秋,周晓军,吴波,马恒辉,周航波,刘晓红,陈洁宇.Xp11.2易位/TFE3基因融合相关性肾癌的病理特征与临床分析[J].中华病理学杂志,2007,36(4):244-246. 被引量：34
  • 3Tazi EM,Essadi I,Tazi MF,et al.Advanced treatments in non-clear renal cell carcinoma[J].Urol J,2011,8(1):1-11.
  • 4Kato H,Kanematsu M,Yokoi S,et al.Renal cell carcinoma associated with Xp11.2translocation/TFE3gene fusion:radiological findings mimicking papillary subtype[J].J Magn Reson Imaging,2011,33(1):217-220.
  • 5Green WM,Yonescu R,Morsberger L,et al.Utilization of a TFE3Break-apart FISH assay in a renal tumor consultation service[J].Am J Surg Pathol,2013,37(8):1150.
  • 6Zhang YY,Luo S,Liu Y,et al.Angiomyolipoma with minimal fat:differentiation from papillary renal cell carcinoma by helical CT[J].Clin Radiol,2013,68(4):365-370.
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  • 9Kondo T,Ikezawa E,Takagi T,et al.Negative impact of papillary histological subtype in patients with renal cell carcinoma extending into the inferior vena cava:single-center experience[J].Int J Urol,2013,20(11):1072-1077.
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引证文献19

二级引证文献42

中华外科杂志
2014年 第2期

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