疑似预防接种异常反应及其与预防接种的因果关系评估

Adverse events following immunization and causality assessment of an adverse event following immunization

2013年12月,媒体报道湖南、广东、四川等地出现接种乙肝疫苗接种后死亡事件,引起社会的普遍关注。当前,疫苗种类和使用的范围、目的更加广泛,临床医生,尤其儿科医生将会面临越来越多的与疫苗有关的临床问题,需要重视学习疫苗学知识。本文介绍了"疑似预防接种异常反应"和"预防接种异常反应"的定义和分类,以及疑似预防接种异常反应与预防接种因果关系评估的意义和结论等有关知识。

Several fatal events occurred in Hunan, Guangdong and Sichuan Province in December, 2013. The events were reported by the news media, which followed growing public concern. Currently, more and more vaccines were developed and the immunization was adopted for more objectives. The clinicians, especially pediatricians will face a growing number of clinical problems related to the vaccine. The clinicians should pay attention to learn more knowledge about vaccines. This article describes the definition and classification of ＂adverse events following immunization＂ and ＂serious vaccine product-related reactions＂, and the signifcance and conclusion of causality assessment following immunization.