促性腺激素释放激素类似物联合重组人生长激素对中枢性性早熟女童身高的影响

Effects of gonadotropin releasing hormone analog and growth hormone on height in girls with idiopathic central precocious puberty

目的研究促性腺激素释放激素类似物(GnRHa)与重组人生长激素(rhGh)联合治疗以及GnRHa单用对骨龄≥10岁的特发性中枢性性早熟(ICPP)女童成年身高的改善情况。方法将6个医学中心确诊为ICPP符合研究条件的80例女童(年龄9.0±0.7岁,骨龄≥10岁)根据治疗方法分为GnRHa与rhGh联合治疗组(31例)及GnRHa单用组(49例)。观察治疗前后的预测成年身高、接近成年身高和身高净获等各项指标的变化。结果两组在治疗后按骨龄的身高标准差分值均较治疗前有显著改善(P<0.01),其中GnRHa与rhGh联合治疗组明显优于GnRHa单用组(P<0.01)。联合用药组接近成年身高(157±6 cm vs 157±4 cm)、身高净获(4.68 cm vs 3.89 cm)、停药时预测成年身高(161±5 cm vs 158±5 cm)、接近成年身高与遗传靶身高差值等指标均略高于GnRHa单用组,但差异无统计学意义(均P>0.05)。结论 GnRHa与rhGh联合治疗或GnRHa单用组均能改善骨龄≥10岁ICCP女童的成年身高,但两药联用优势不明显。对ICPP患儿预测成年身高的评估需要慎重,停药时的预测值偏高。

Objective To determine the effect of gonadotropin releasing hormone agonist （GnRHa）, by itself alone or in combination with recombinant human growth hormone （rhGH）, on height in young girls （bone age〉10 years） with idiopathic central precocious puberty （ICPP）. Methods Eighty girls with ICPP （9.0±0.7 years old） from six medical centers across Southeast and Southwest China participated in this study. They were allocated to treatment with GnRHa＋rhGH （n=31） and GnRHa （n=49） respectively. Girls in the GnRHa＋rhGH group （bone age 11.18 ±0.53 years） were treated with GnRHa for 25.29±6.92 months and rhGH for 12.87±7.02 months. Girls in the GnRHa group （bone age 11.03 ±0.50 years） were treated with GnRHa for 25.96±8.95 months. The height standard deviation for bone age （HtSDS-BA）, predicted adult height, near-adult height and net height increase before and after treatment were recorded for girls in both groups. Results HtSDS-BA was significantly improved after treatment for both groups （P〈0.01） and the HtSDS-BA value was superior in the GnRHa＋rhGH group over the GnRHa group （P〈0.01）. Values in near adult height （157±6 cm vs 157±4 cm）, net height increase after treatment （4.68 cm vs 3.89 cm）, and predicted adult height after drug withdrawal （161±5 cm vs 158±5 cm） were higher in the GnRHa＋rhGH group than the GnRHa group, but the differences were not significant. Conclusions Both GnRHa plus rhGH and GnRHa alone can improve the near adult height in girls with ICPP with a bone age 〉10 years to a similar extent. Adult height predicted based on bone age in ICPP girls following drug withdrawal is usually overestimated and precautions should be taken when this parameter is used.