甘精胰岛素联合二甲双胍治疗2型糖尿病的疗效

Efficacy of combined use of glargine and metformin in treating type 2 diabetes mellitus

目的探讨甘精胰岛素联合二甲双胍治疗2型糖尿病(T2DM)的临床疗效。方法 T2DM患者48例随机均分为两组:A组采用甘精胰岛素皮下注射加二甲双胍口服;B组单用门冬胰岛素30皮下注射。比较两组疗效。结果治疗前,两组患者体重指数(BMI)、C肽(C-P)、空腹血糖(FBG)、餐后2-h血糖(P2-hBG)和糖化血红蛋白(HbA1c)均无统计学差异(P>0.05)。治疗后,两组FBG、P2-hBG和HbA1c低于治疗前(P<0.05),A组低于B组[(6.8±1.1)mmol/L vs.(8.2±1.7)、(8.1±1.6)mmol/L vs.(9.8±2.1)mmol/L和(7.0±1.2)%vs.(8.7±1.7)%](P<0.05)。A组治疗后BMI低于治疗前,且低于B组[(23.3±2.6)kg/m2 vs.(26.4±2.5)kg/m2](P<0.05)。两组治疗后C-P与治疗前比较均无统计学差异(P>0.05)。结论甘精胰岛素联合二甲双胍治疗T2DM疗效优于单纯胰岛素治疗。

Objective To investigate the efficacy of combined use of glargine and metformin in treating type 2 diabetes mellitus（T2DM）. Methods Forty-eight T2DM patients were randomly and equally assigned into two groups of A （treated with glargine subcutaneous injection and oral metformin） and B（treated with insulin aspart 30 alone）. The efficacy was compared between two groups before and after treatment. Results There were no significant defferences in body mass index （BMI） ,C-peptide（C-P）, fasting blood glueose（FBG）, postprandial 2-h blood glucose （P2-hBG） and glyeated hemoglobin （HbAlc）（P〉0. 05）. The levels of FI3G, P2-ht and HbAlc were lower after treatment than those before in both groups（P〈0. 05）, which after treatment were lower in group A than those in group B（P〈0. 05）. After treatment, BMI of group A was lower than that before and that of group BE（23.3±2.6） kg/m2 vs： （26.4±2. 5） kg/m2]（P〈0. 05）. Compared to before, C-P level was not significantly changed after treatment in both groups（P〉0. 05）. Conclusion The efficacy of combined use of glargine and metformin is better than that of insulin aspart alone in treating T2DM.