格林巴利综合征的临床特征及治疗转归

Clinical features and outcomes of Guillain-Barré syndrome

目的总结38例格林巴利综合征(GBS)患者的治疗与转归。方法回顾性分析38例GBS患者的临床资料。结果 38例中,27例(71.1%)以四肢远端无力为首发症状,少数以腹痛腹泻、头晕头痛等其他表现起病。经激素和/或丙种球蛋白治疗后,治愈29例,好转5例,无效1例,自动出院3例。结论 GBS多数以四肢无力起病。GBS患者多数预后较好。激素对轻、中型GBS患者有一定疗效;丙种球蛋白能明显改善重型及极重型GBS患者预后,降低病死率。

Objective To summarize the clinical features and outcomes of Guillain-Barr6 syndrome（GBS）. Methods Clinical data of 38 GBS patients were retrospectively analyzed. Results Of 38 cases,27 cases（71.1%） presented weakness of distal limbs as a primary symptom and some of the patients manifested with abdominal pain, diarrhea, dizziness, headache and other symptoms at onset. After treated with corticosteroids and/or intravenous immunoglobulin, 29 cases were cured, 5 cases improved,and one patient non-responsive. Other 3 cases gave up treatment. Conclusion The majority of the patients with GBS present weakness of the limbs at onset and with a good prognosis. Mild to moderate GBS patients are responsive to corticosteroids therapy. Immunoglobulin is effective in severe GBS cases with significantly improved prognosis and decreased mortality.