两种检测技术对比1990-2011年玉溪市暗娼HIV-1感染态势

Observation on the Infection Trend of HIV Among Female Sex Workers with Two Kinds of Testing Technology in Yuxi,Yunnan,1990- 2011

目的分析1990-2011年玉溪市暗娼（FSWs）人群HIV-1感染态势，旨在合理估算HIV-1在玉溪市暗娼中的流行态势。方法时1990-2011年玉溪市相关场所的暗娼用HIV-1BED捕获酶免疫测定法（BED-CEIA）和微量HIV-1抗体明胶颗粒凝聚法（ML-PA）进行HIV-1新发感染率检测，并采用ML-PA和BED-CEIA对HIV-1新近感染态势进行估算。结果共计纳入样本20288份，检出HIV-1阳性214份，1990-1996年感染率均为0，1997-2011年为0．61％-1．40％，流行趋势差异有统计学意义（P〈0．05）。HIV-1新发感染率：ML-PA法2006-2011年为0．00～2．31／1000人年，BED-CEIA法2005-2011年为0．00～5．89／1000人年，流行趋势差异无统计学意义（P〉0．05）。结论玉溪市暗娼人群艾滋病流行处于较低水平，且呈下降趋势，两种检测方法的结论-致，但缺乏-致性。

Objective To analyse the trend of HIV-1 infection among female sex workers （FSWs） in Yuxi from 1990 to 2011, and reasonably estimate the HIV-1 epidemic situation among FSWs. Methods FSWs who were all came from the related places, and were detected of HIV-1 incidence by HIV-1 BED capture enzyme immuno- assay（BED-CEIA） and traced HIV-1 antibody gelatin particle agglutination method（ ML-PA）, and the trend of HIV-1 infection were estimated by the above two methods. Results A total of 20 288 samples were in- cluded, among of them 214 samples were positive for HIV-1. The rates of HIV-1 infection were 0 from 1990 to 1996, 0.61% in 1997 to 1.40% in 2011, and the trend of HIV had significance（P 〈 0.05 ）. The inci- dence of HIV-1 was 0.00 to 2.31 per 1000 person years（pys） with the ML-PA from 2006 to 2011, 0 to 5.89 per 1000 pys with the BED-CEIA from 2005 to 2011, and the trend of HIV had no significance（P 〉 0. 05 ）. Conclusion The HIV epidemic among female sex workers is low and has descend trend. The results of two methods of HIV - 1 incidence are the same, but there had no consistency.