皮肤假性淋巴瘤1例

A Case of Cutaneous Pseudolymphoma

患者男,69岁。鼻部肿物伴瘙痒1月余。皮肤科情况:右鼻翼处见一直径约1.5cm大小的暗红色结节,界清,表面光亮,可见少许毛细血管扩张,无破溃和压痛。皮损组织病理示:表皮大致正常,真皮内可见弥漫性淋巴样细胞为主的浸润,其内伴散在异型淋巴细胞,未侵及表皮,境界带明显;免疫组织化学染色示:CD3,CD4,CD5,CD8,CD20,CD43,CD56均散在阳性,PAX5+,TIA-1散在,CD30-,EVB-,Ki-67index3%。诊断:假性淋巴瘤。予3次封闭治疗后皮损基本平复,治疗后2年时皮损已完全消退。随访至今,未见复发。

A 69-year-old male presented with a red tumor which caused an itch on the＇ nose for more than 1 month. Dermatology examination：a dark red nodule on the right nasal ala with 1.5 cm in diameter, clear boundary, a lit tle of telangiectasis and shiny surface, without ulcerating and pain. Histopathological examination showed roughly normal epidermal and lymphocyte diffuse infihration in the dermis, with some atypical lymphocytes. Lymphocytes didn＇t invade the epidermal, following a obviously frontier zone. Immunohistochemically, there were scattered positive cells for CD3 , CD4, CD5, CDS , CD20 , CD43, CD56 ,PAX5, weak positive for TIA-1, negative for CD30 ,EVB,a 3% proliferation index for Ki-67. A diagnosis of cutaneous pseudolymphoma was made. The lesion improved after 3 times of part blocking therapy and completely regressed after 2 years. A follow up visit to now,without relapse.