尖锐湿疣局部免疫功能抑制及其机制的研究进展

The Local Immunosuppression and Its Mechanism in Condyloma Acuminatum: An Update

尖锐湿疣(condyloma acuminatum,CA)是由人乳头瘤病毒(human papillomavirus,HPV)感染引起的一种常见的性传播疾病。目前的研究认为其皮损局部免疫功能抑制和HPV持续感染相互影响,是CA复发的主要原因。近5年的文献显示HPV可通过干扰树突状细胞抗原提呈、降低NK细胞活性、影响T淋巴细胞与调节性T细胞数量及功能、影响Toll样受体的识别以及干扰相关细胞因子的表达形成局部免疫抑制。深入研究CA患者免疫功能现象及机制有助于为其发病机制和治疗提供新的靶标。

Condyloma acuminatum（ CA）, as a common sexually transmitted disease, is caused by human papillomavir us（HPV） infection. Previous studies indicated that interaction between local immune suppression in the le sions and persistent HPV infection contributed greatly to CA recurrence. Herein, we have reviewed related studies in the last five years and found that：HPV infection leads to local immunosuppression by interfering with antigenpresenting dendritic ceils, T ceils and regulatory T ceils, decreasing NK cell bioactivity, pre venting the recognition of Toll like receptors, and suppressing related cytokine expression. Through indepth study of immune response in CA, we will come to a better understanding of HPV pathogenesis and to uncove ring new ways to fight against recurrence.