60例脊柱疾病术后舒芬太尼复合氟比洛芬酯镇痛效果分析

Analgesia effect analysis on 60 cases of spinal disease sufentanil compound flurbiprofen ester postoperative

目的：探讨舒芬太尼复合氟比洛芬酯用于脊柱手术后镇痛效果。方法：选取我院2011年1月～2012年12月ASAⅠ-Ⅱ级择期骨科脊柱手术患者180例，随机分为A、B、C 3组，每组各60例。3组患者手术结束后即行患者静脉自控镇痛PCIA。 A组术后镇痛用舒芬太尼2g/kg＋生理盐水至100mL。B组舒芬太尼2g/kg＋氟比洛芬酯150mg＋生理盐水至100mL。 C组舒芬太尼4g/kg＋生理盐水至100mL。3组PCIA泵参数设置：背景剂量2ml，单次负荷剂量2ml ，锁定时间15分钟。观察3组患者术后2小时、6小时、12小时、24小时、48小时的静息镇痛评分及PCIA期间恶心、呕吐、头晕、嗜睡、呼吸抑制不良反应发生情况。结果：术后各时间点VAS评分，A组评分高于B组和C组（P＜0．05）， B组和C组镇痛效果良好，B、C 2组VAS评分无统计学意义（P＞0．05））。 PCIA期间不良反应观察中，A、B 2组恶心呕吐，头晕嗜睡的患者均少于C组，并且C组中有2例呼吸抑制，差异有统计学意义（ P＜0．05）。结论：舒芬太尼复合氟比洛芬酯用于脊柱手术后镇痛的效果好，各种不良反应发生率低。

Objective：To study the compound flurbiprofen sufentanil esters used in effect of analgesia after spinal surgery .Methods：180 cases ASA grade Ⅰ -Ⅱelective orthopaedic spinal surgery patients in our hospital from January 2011 to December 2011 , randomly divided into A, B, C three groups, each group 60 cases.Three groups of patients after surgery in patients with venous self -control anal-gesia PCIA.Postoperative analgesia with sufentanil group A （including 2g/kg ＋saline water to 100 ml.Sufentanil group B （including 2 g flurbiprofen ester 150 mg/kg ＋＋saline to 100 ml.Sufentanil group C （ including 4 g -100 -ml/kg ＋saline water .Three groups of PCIA pump parameters Settings：background dose 2 ml, a single load 2 ml dose, the lock time of 15 min.Observe three groups of pa-tients after 2 h, 6 h, 12 h, 24 h, 48 h resting analgesia scores and during PCIA nausea , vomiting, dizziness, drowsiness, respiratory in-hibition adverse reactions occur .Results：Postoperative VAS score at each time point , group A score higher than that of group B and group C （P〈0.05）, group B and group C analgesic effect is good ,B, C, two groups of VAS score no statistical significance （P 〉0.05））. PCIA adverse reactions during the period of observation , A,B two groups, nausea, vomiting, dizziness, sleepiness in patients were less than group C , and there are two cases of respiratory inhibition in group C , the difference was statistically significant （P 〈0.05）.Con-clusion：Sufentanil compound flurbiprofen esters used in analgesia after spinal surgery effect might be good , all kinds of bad reaction inci-dence was low .