期刊文献+

60例脊柱疾病术后舒芬太尼复合氟比洛芬酯镇痛效果分析 被引量:1

Analgesia effect analysis on 60 cases of spinal disease sufentanil compound flurbiprofen ester postoperative
原文传递
导出
摘要 目的:探讨舒芬太尼复合氟比洛芬酯用于脊柱手术后镇痛效果。方法:选取我院2011年1月~2012年12月ASAⅠ-Ⅱ级择期骨科脊柱手术患者180例,随机分为A、B、C 3组,每组各60例。3组患者手术结束后即行患者静脉自控镇痛PCIA。 A组术后镇痛用舒芬太尼2g/kg+生理盐水至100mL。B组舒芬太尼2g/kg+氟比洛芬酯150mg+生理盐水至100mL。 C组舒芬太尼4g/kg+生理盐水至100mL。3组PCIA泵参数设置:背景剂量2ml,单次负荷剂量2ml ,锁定时间15分钟。观察3组患者术后2小时、6小时、12小时、24小时、48小时的静息镇痛评分及PCIA期间恶心、呕吐、头晕、嗜睡、呼吸抑制不良反应发生情况。结果:术后各时间点VAS评分,A组评分高于B组和C组(P<0.05), B组和C组镇痛效果良好,B、C 2组VAS评分无统计学意义(P>0.05))。 PCIA期间不良反应观察中,A、B 2组恶心呕吐,头晕嗜睡的患者均少于C组,并且C组中有2例呼吸抑制,差异有统计学意义( P<0.05)。结论:舒芬太尼复合氟比洛芬酯用于脊柱手术后镇痛的效果好,各种不良反应发生率低。 Objective:To study the compound flurbiprofen sufentanil esters used in effect of analgesia after spinal surgery .Methods:180 cases ASA grade Ⅰ -Ⅱelective orthopaedic spinal surgery patients in our hospital from January 2011 to December 2011 , randomly divided into A, B, C three groups, each group 60 cases.Three groups of patients after surgery in patients with venous self -control anal-gesia PCIA.Postoperative analgesia with sufentanil group A (including 2g/kg +saline water to 100 ml.Sufentanil group B (including 2 g flurbiprofen ester 150 mg/kg ++saline to 100 ml.Sufentanil group C ( including 4 g -100 -ml/kg +saline water .Three groups of PCIA pump parameters Settings:background dose 2 ml, a single load 2 ml dose, the lock time of 15 min.Observe three groups of pa-tients after 2 h, 6 h, 12 h, 24 h, 48 h resting analgesia scores and during PCIA nausea , vomiting, dizziness, drowsiness, respiratory in-hibition adverse reactions occur .Results:Postoperative VAS score at each time point , group A score higher than that of group B and group C (P〈0.05), group B and group C analgesic effect is good ,B, C, two groups of VAS score no statistical significance (P 〉0.05)). PCIA adverse reactions during the period of observation , A,B two groups, nausea, vomiting, dizziness, sleepiness in patients were less than group C , and there are two cases of respiratory inhibition in group C , the difference was statistically significant (P 〈0.05).Con-clusion:Sufentanil compound flurbiprofen esters used in analgesia after spinal surgery effect might be good , all kinds of bad reaction inci-dence was low .
作者 吕萍
出处 《中国伤残医学》 2014年第4期17-18,共2页 Chinese Journal of Trauma and Disability Medicine
关键词 氟比洛芬酯 舒芬太尼 骨科脊柱手术 镇痛效果 Flurbiprofen ester Sufentanil Orthopaedic spinal surgery Analgesic effect
  • 相关文献

参考文献5

二级参考文献10

  • 1徐国柱,李晓玲,段砺瑕,朱天岳,谢启伟,周应芳,王冰,邓艳萍,沈黎阳,袁旭.氟比洛芬酯脂微球载体注射液治疗中度术后疼痛的Ⅱ期临床试验[J].中国新药杂志,2004,13(9):846-848. 被引量:258
  • 2[1]Bailey PL,Streisand JB,East KA,et al.Differences in magnitude and duration of opioid-induced respiratory depression and analgesia with fentanyl and sufentanil.Anesth analg,1990,70:8-15.
  • 3[2]Geller E,Chrubasik J,Graf R,et al.A randomized double-blind comparison of epidural or epidural sufentanil versus intravenous sufentanil or epidural fentanyl analgesia after major abdominal surgery.Anesth analg,1993,76:1243-1250.
  • 4[1]Ohmukai O.Lipo-NSAID preparation[J].Adv Drug Deliv Rev,1996,20(2-3):203-207.
  • 5[4]Kuriyama K,Hiyama Y,Aoyama Y,et al.Pharmacological studies of a non-steroidal analgesic and antipyretic drug of LFP83[J].Nippon Yakurigaku Zasshi,1989,93(2):61-73.
  • 6[6]Davis NM.Clinical pharmacokinetics of flurbiprofen and its enantiomers[J].Clin Pharmacokinet,1995,28(2):100-114.
  • 7[7]Mikawa K,Nishina K,Maekawa N,et al.Dose-response of flurbiprofen on postoperative pain and emesis after paediatric strabismus surgery[J].Can J Anaesth,1997,44(1):95-98.
  • 8[8]Machida K,Tsutsui T,Kaneko A,et al.Convulsion following the combination of single preoperative oral administration of enoxacine and single postoperative intravenous administration of flurbiprofen axetil[J].Jpn J Anesth,2001,50(4):425-428.
  • 9王亚敏.新型药物载体:脂质微球[J].国外医学(药学分册),1997,24(5):305-308. 被引量:70
  • 10酆锋.消炎、镇痛药——氟比洛芬(Flurbiprofene)[J].山东医药工业,1998,17(1):35-36. 被引量:27

共引文献810

同被引文献4

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部