磁共振扩散加权成像和信号增强率对肝脏原发癌立体定向放射治疗的疗效评价

With the diffusion- weighted magnetic resonance imaging and signal enhancement ratio to evaluate the value of three- dimensional conformal radiotherapy on primary hepatic carcinoma

目的:探讨磁共振扩散加权成像(DWI)和动态增强成像(DCEI)后测量的信号增强率(SER)在评价肝脏原发癌(PhC)立体定向放射治疗后的疗效,并探讨两者的关联性。方法:收集确诊肝癌病人34例,分别于放射治疗前、放射治疗15天、治疗完成、完成后1个月、完成后3个月时行磁共振DWI和动态增强检查,比较各期病灶大小、ADC值以及SER的差异,分析放射治疗后ADC值改变与SER改变之间的关联性。结果:肝癌在立体定向放射治疗早期体积无明显变化,放射治疗前、放射治疗15天、治疗完成、完成后1个月、完成后3个月ADC值:(1.053士0.194)×10-3mm2/s,(1.059士0.146)×10-3mm2/s;(1.104士0.129)×10-3mm2/s;(1.167士0.185)×10-3mm2/s;(1.244士0.133)×10-3mm2/s。SER:127.55±22.32;122.91±22.80;108.59±23.10;;83.36±23.55;47.61±22.36。结论:肝癌在立体定向放射治疗后各期的ADC值与DCEI测量的SER存在一定的关系,两者结合有助于肝癌立体定向放射治疗的疗效评价。

Objective：To learn the correlation between the diffusion -weighted magnetic resonance imaging （ DWI） and the signal en-hancement ratio （ SER） .By them to evaluate the value of three dimensional conformal radiotherapy on primary hepatic carcinoma （ PhC） . Methods：34 cases who suffering PhC were collected in this study , all of them had been underwent examination including diffusion -weighted magnetic resonance and dynamic -contrast enhanced magnetic resonance .then measure the size , SER and ADC of tumor before the treatment of three dimensional conformal radiotherapy in the follow period ：3 days before treatment , after 15 days, treatment were com-pleted, treatment were completed one month , treatment were completed one month .Results：The size of tumor had no significant change after 2 month treatment of three-dimensional conformal radiotherapy .the average ADC at the five points are as follows：（1.053±0.194 ） ×10-3mm2/s,（1.059±0.146 ） ×10-3mm2/s;（1.104±0.129 ） ×10-3mm2/s;（1.167±0.185 ） ×10-3mm2/s;（1.244±0.133 ） ×10-3mm2/s. Average SER：127.55 ±22.32;122.91 ±22.80;108.59 ±23.10;83.36 ±23.55;47.61 ±22.36. Conclu-sion：ADC and SER has certain relationships in the three -dimensional conformal radiotherapy of PhC .It＆#39;s helpful for doctors to learn the value of PhC after three-dimensional conformal radiotherapy by combination the two parameters .