炎症因子与肺癌研究进展

Research situation of inflammation factors and lung cancer

目的:总结分析炎症因子在肺部肿瘤患者血清中的表达水平及其与肺部肿瘤临床病理特征间的关系及相关性。方法:应用PubMed及CNKI期刊全文数据库检索系统,以"炎症、肿瘤和肺"为关键词,检索年限为1996-01-2013-10。共检索到113篇文献,其中英文文献91篇,中文文献22篇。纳入标准:1)炎症因子的增加或减少与肺部肿瘤的关系;2)炎症因子成为治疗炎症相关性肺部肿瘤的重要靶点。根据纳入标准分析其中40篇文献。结果:白细胞介素-6(interleukin-6,IL-6)、移动抑制因子相关蛋白和高迁移率族蛋白B1均属于促炎因子,在肿瘤的发生和发展中具有重要作用。IL-10和IL-13属于抑炎因子,在恶性肿瘤生长和转移的过程中可以产生截然相反的结果。结论:炎症因子与肺部肿瘤的发生、发展具有相关性,可以促进恶性细胞的增殖和存活,削弱机体的获得性免疫反应,对患者的诊断、治疗及预后有重要意义。

OBJECTIVE：To review inflammation factors expression level in lung cancer patients,and analyze the rela- tionship of various factors in inflammation and lung cancer. METHODS： A total of 113 papers were searched with inflam- mation, tumor and lung as the key words in CNKI and PubMed database from 1996 January to 2013 October,22 papers of literature in Chinese and 91 in English were dotained. The selection standards for the date related：The relationship of in- creased or decreased inflammation factors and lung cancer; Inflammation factors become the important target of lung canc- er. Forty papers were finally selected and analyzed. RESULTS： IL-6, migration inhibitory factor-related protein and the high-mobility group box 1 are proinflammatory factors, which play important roles in the initiation and progression of tumor. IL-10 and IL-13 are belong to the suppression of inflammatory factors, which may produce the opposite results in the growth and metastasis of malignant tumor. CONCLUSION： Inflammation factors in the tumor microenvironment have a variety of tumor-promoting effects which related to proliferation and survival of malignant cells and weaking the body＇s acquired immune response, and have significance for the patient＇s diagnosis, treatment and prognosis.