胃肝样腺癌的临床特征与预后

Clinical characteristics and prognosis of hepatoid adenocarcinoma of the stomach

胃肝样腺癌（HAS）是一种具有肝样分化区域的特殊类型胃癌。血清甲胎蛋白（AFP）的产生是HAS一种特征性表现。HAS的发生机制尚不明确，目前相关研究大多为病例报告，缺少大样本病例的研究。HAS的预后很差，肝转移率较高，其生物学行为与普通胃癌有明显区别。无肝转移灶时，胃癌根治术是主要的治疗手段，但目前对于肝转移灶的治疗方案尚无一致结论，血清AFP检测对此类肿瘤的早发现、早诊断以及对患者疗效监控、预测肿瘤的复发与转移均有重要临床意义。

Hepatoid adenocarcinoma of the stomach （HAS） is a special type of gastric cancer characterized with hepatoid differentiation and the production of large amounts of α-fetoprotein （AFP）. The pathogenesis of HAS is still not clear. Most of the relative studies are single case reports, and studies with large sample are absent. The prognosis of HAS is poor. HAS has a high rate of liver metastasis. The biology behaviors of HAS differ from common gastric cancers. Radical resection of the gastric cancer is considered to be the main treatment when no liver metastasis is found, while the treatment regimens of the metastasis lesions are still in debate. The serum AFP test is important for the early detection and diagnosis of HAS, and it is crucial for monitoring the therapeutic effect and the relapse and metastasis of the tumor.