EBV相关恶性肿瘤的新病毒靶向性治疗研究进展

The progress of virus-targeted new therapy against Epstein-Barr virus-associated malignancies

EB病毒(Epstein-Barr virus,EBV)被证明与多种人类恶性肿瘤相关,如鼻咽癌(nasopharyngeal carcinoma,NPC)、Burkitt淋巴瘤(Burkitt’s lymphoma,BL)、移植后淋巴组织增生症(post-transplant lymphoproliferative disease,PTLD)、霍奇金淋巴瘤(Hodgkin’s lymphoma,HL)、非霍奇金淋巴瘤(non-Hodgkin’s lymphomas,NHL)以及胃癌(gastric cancer,GC)等。在大部分EBV相关性恶性肿瘤中,几乎所有的癌细胞内都包含病毒基因组,这为人们提供了种以EBV基因组作为靶点,治疗EBV相关恶性肿瘤的潜在可能。本综述主要描述EBV相关恶性肿瘤的病毒新靶向治疗的新研究进展,并深入探讨了药物诱导病毒活化作为肿瘤治疗手段的可能性及其相关信号通路。

The Epstein-Barr virus （EBV） has been demonstrated to be associated with several human tumors, including nasopharyngeal carcinoma （NPC）, Burkitt＇s lymphoma （BL）, post-transplant lymphoproliferative disease （PTLD）, Hodgkin＇s lymphoma （HL）, non-Hodgkin＇s lymphomas （NHL） and gastric cancer （GC）. In most EBV-associated malignancies, the tumor cells contain the viral genome. This provides a unique opportunity to develop therapeutic strategies utilizing the viral genome of EBV as a potential drug target. This review focuses on different therapeutic strategies against EBV-associated malignancies, further discusses the possible therapeutic approach using drug-induced virus activation and its certain pathways.