瑞舒伐他汀对不稳定型心绞痛患者血脂及hs-CRP的影响

Effect of rosuvastatin on blood lipids and hs-CRP of patients with unstable angina pectoris

目的探讨瑞舒伐他汀治疗不稳定型心绞痛的疗效，以及对患者血脂及hs—CRP的影响。方法选择2010年1月～2012年1月在我院住院接受治疗的UAP患者共60例，全部患者随机分为观察组对照组各30例，两组均予吸氧、β受体阻断剂、硝酸酯类、钙拮抗剂、ACEI、低分子肝素、肠溶阿斯匹林，伴有其他疾病者对症处理。观察组同时予瑞舒伐他汀钙片20mg，每日1次，睡前口服，疗程8周。对照组予辛伐他汀作对照，辛伐他汀40mg，每晚一次口服，疗程8周。比较两组患者治疗后的疗效及Tc、TG、LDL、HDL、hs—CRP水平的变化情况。结果对照组治疗8周后无效7例，有效率仅76．7％，观察组治疗8周后无效3例，有效率达90．0％，两组疗效比较结果显示，观察组的疗效明显优于对照组，差异有统计学意义（P〈0．05）。观察组治疗后的TC、TG、LDL均较治疗前及对照组显著降低，而HDL明显升高，组间比较，差异有统计学意义（P〈0．05）。观察组和对照组患者治疗前hs—CRP比较差异不显著，治疗后8周后，观察组和对照组的hs—CRP水平组间比较差异有统计学意义（P〈0．05）。结论瑞舒伐他汀可以降低不稳定型心绞痛患者血脂水平，及降低hs—CRP水平，提高疗效，值得广泛推广和应用。

Objective To investigate the efficacy of rosuvastatin in the treatment of unstable angina pectoris（UAP）,and the influence on blood lipids and Hs-CRP of patients. Methods 60 inpatients with UAP from January 2010 to January 2012 in our hospital were randomLy divided into the observation group and the control group according to the order of admission,each group had 30 patients.The patients of the two groups were given oxygen inhalation, 13 blockers,nitrates,calcium antagonists, ACEI,low molecular weight heparin,enteric-coated aspirin,and symptomatic treatment when accompanying by other diseases.The patients of the observation group on the basis of above treatment were given 20rag rosuvastatin calcium, once daily,orally at bedtime for 8 weeks.The patients of the control group on the basis of above treatment were given 40mg simvastatin,orally once every night for 8 weeks. The efficacy and changes of TC,TG,LDL,HDL,hs-CRP level of patients in the two groups were compared after the treatment. Results In the control group after 8 weeks of treatment,7 cases were ineffective,the effective rate was only 76.7%,while in the observation group after 8 weeks of treatment,3 cases were ineffective,the effective rate was 90.0%,the Comparison of curative effect between two groups showed that the curative effect of the observation group was better than that of the control group, the difference was statistically significant（P 〈 O.05）.Compared with the observation group before the treatment and the control group after the treatment, the TC,TG,LDL level of the observation group after the treatment decreased significantly,while HDL increased significantly,the differences were statistically significant（P 〈 0.05）. There was not significant difference in the Hs-CRP level before the treatment between two groups,and significant difference in the hs-CRP level after 8 weeks of treatment between two groups （P 〈 0.05）. Conclusion Rosuvastatin can reduce the blood lipids and Hs-CRP level of patients with unstable angina pectoris,improve the efficacy,and is worthy of extensive promotion and application.