瘦素受体基因多态性与中国人群高血压相关性的meta分析

Association of leptin receptor gene polymorphisms with hypertension in Chinese population:a meta-analysis

目的：评价中国人群瘦素受体（LEPR）基因多态性与高血压的相关性。方法以“Hypertension”“、Blood Pressure, high”、“Leptin Receptor”“、OB Receptor”“、LEPR Protein”“、CD295 Antigens”“、LEPR”“、高血压”“、瘦素受体”“、OB受体”“、CD295抗原”为检索词，全面检索中国人高血压与LEPR基因多态性相关性的文献，用RevMan 5.0和Stata 11.0进行Meta分析。结果共纳入13篇病例对照研究，包含3210例病例和1881例对照，meta分析显示，LEPR基因Gln223Arg位点多态性在等位基因和显性遗传模型下与高血压相关（等位基因模型：OR=1.78，95%CI=1.48~2.15，P＆lt;0.0001；显性遗传模型：OR=2.18，95%CI=1.75~2.72，P＆lt;0.00001），Lys109Arg位点多态性与高血压无统计学相关性（等位基因模型：OR=1.13，95%CI=0.84~1.51，P=0.42；隐性遗传模型OR=0.88，95%CI=0.33~2.32，P=0.79；显性遗传模型OR=1.20，95%CI=0.85~1.71，P=0.29；加性遗传模型OR=0.90，95%CI=0.34~2.42，P=0.84）。结论中国人LEPR基因Lys109Arg位点多态性与高血压无显著相关性，在等位基因和显性遗传模型下，Gln223Arg位点多态性与高血压相关，A等位基因是中国人高血压发生的危险基因。

Objective To evaluate the association between leptin receptor gene polymorphisms and hypertension in Chinese population. Methods The keywords＆quot;Hypertension＆quot;,＆quot;Blood Pressure, high＆quot;,＆quot;Leptin Receptor＆quot;,＆quot;OB Receptor＆quot;,＆quot;LEPR Protein＆quot;,＆quot;CD295 Antigens＆quot;, and ＆quot;LEPR＆quot; were used to search the literature to identify the relevant studies for meta-analysis using software RevMan 5.0 and Stata 11.0 software. Results Thirteen studies involving 3210 cases of hypertension and 1881 controls were included in the meta-analysis. Overall, a significant association was found between Gln223Arg gene polymorphism and hypertension in allele contrast and dominant genetic model （for allele contrast genetic model： OR=1.17, 95%CI=1.48-2.15, P＆lt;0.0001;for dominant model：OR=2.18, 95%CI=1.75-2.72, P＆lt;0.00001）. No statistically significant correlation was found between Lys109Arg polymorphism and hypertension （for allele model：OR=1.13, 95%CI=0.84-1.51, P=0.42;for recessive genetic model：OR=0.88, 95%CI=0.33-2.32, P=0.79;for dominant genetic model：OR=1.20, 95%CI=0.85-1.71, P=0.29;for additive genetic model：OR=0.90, 95%CI=0.34-2.42, P=0.84）. Conclusion There is no significant correlation between Lys109Arg variant of LEPR gene and hypertension in Chinese population, but the Gln223Arg polymorphism is associated with hypertension in allele contrast and dominant genetic model. Chinese population with an A allele are at a high risk of developing hypertension.