青少年网络游戏成瘾者在线索诱发条件下大脑的PET研究

The brain PET study of adolescent internet gaming addicts following game-cues exposure

目的通过研究网络游戏成瘾(IGA)者在线索诱发条件下大脑神经活动的PET影像,探索与IGA相关的机制。方法 10例IGA组和10例健康志愿者(对照组)参与本研究,以两因素重复测量方差分析进行数据处理。结果线索因素同被试因素之间存在显著交互作用,激活的主要脑区有枕叶、顶叶、颞叶、楔前叶、扣带回和前额叶皮质。IGA组观看游戏线索与风景线索相比奖赏系统显著激活,且IGA组减少了视觉空间网络(枕叶、中央后回等)的神经激活。在观看游戏线索的条件下,IGA组相比于对照组,枕叶、楔前叶和缘上回代谢增加,而中央后回代谢降低。结论研究认为枕叶和中央后回等视空网络代谢活动的降低可能代表着IGA者视空处理功能的损害。视空网络代谢的降低和奖赏系统活动的增加可能正是IGA者沉迷于游戏的原因。

Objective PET imaging has been employed to study cue-reactivity-induced neural correlates in internet gaming addiction （IGA） subjects. Methods Ten fight-handed IGA subjects and 10 age-matched normal subjects participated in this study. Cue-reactivity paradigms were employed, and the PET datasets were analyzed with SPM8 software and repeated two-way ANOVA was employed for factorial analyses. Results Neural correlates of factorial interactions between cue-factor and subject-factor were identified in regions of left and right occipital cortex, left parietal cortex, temporal lobe, left precunens, anterior cingulate cortex, prefrontal cortex. The cue-reactivity paradigms significantly increased the activation of reward systems, and deactivation in the neural activations of the visual-spatial networks （occipital cortex, posteentral gyrus） in IGA group. For the cue-factor comparison, the IGA group showed increased metabolism in occipital cortex, precuneus, and supramarginal gyrus and decreased responses in the parietal cortex to game-cues.Contusion It is suggested that the reduced metabolism in brain ＂visual-spatial networks＂ may standing for the impaired visual-spatial processes function in IGA subjects. The combination of reduced metabolism of visual-spatial networks and enhanced brain activities in the reward system and may characterize IGA subjects addicted to the endless game playing.