急性心肌梗死患者血小板平均体积与临床并发症的相关性

Relationship between mean platelet volume and complication in patients with acute myocardial infarction

目的：探讨血小板平均体积（MPV）与急性心肌梗死（AMI）患者住院期间并发症之间的关系。方法：回顾性分析AMI患者220例,根据入院时MPV水平四分位分组：Q1组（MPV≤9.62fL）,Q2组（MPV 9.79~11.08fL）,Q3组（MPV 11.09~12.37fL）,Q4组（MPV≥12.38fL）。每组55例,进行AMI并发症发生危险因素的Logistic回归分析;计算不同MPV水平并发症发生风险的优势比。采用二元变量相关分析MPV与凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）和纤维蛋白原（FBG）、国际标准化比值（INR）的相关性。结果：AMI患者MPV水平与并发症发生风险之间存在正相关性,调整了年龄、性别、吸烟史、糖尿病、高血压病、血小板其他参数、凝血功能指标、心肌肌钙蛋白（cTnI）、左室射血分数（LVEF）、梗死部位、梗死面积和治疗方式等因素后显示：MPV水平最高四分位数患者发生并发症的风险是最低四分位数患者的1.79倍（95%CI：1.26~2.41,P〈0.05）。结论：MPV增高与AMI患者并发症可能密切相关。

Objective：To investigate the relationship between mean platelet volume（MPV）level and risk of complication in acute myocardial infarction（AMI）patients.Method：All 220consecutive AMI patients were divided into quartiles based on MPV value（≤9.62fL,9.79~11.08fL,11.09~12.37fL,≥12.38fL,n=55in each quartile）,and odds ratio（OR）of incident complication was calculated by Logistic regression.Correlation of MPV with coagulation parameters was conducted by Bivariate correlation analysis.Result：MPV levels were positively associated with complication risk.After adjustment for age,gender,smoking history,hypertension,platelet other parameters,coagulation parameters,cTnI,estimated left ventricular ejection,infarct location,infarct size and treatment,the highest RDW quartile entailed 1.79times greater risk for complication than the lowest quartile（95%CI：1.26~2.41,P0.05）.Bivariate correlation analysis showed that MPV was related to coagulation parameters respectively（all P0.05）.Conclusion：High MPV is closely associated with in-creased risk of complications in patients with AMI.