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生长分化因子5调控细胞分化机制研究新进展 被引量：3

Research Progress in Mechanism of Growth Differentiation Factor-5 Regulation on Cell Differentiation
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摘要 生长分化因子5(GDF-5)属于转化生长因子β超家族,成熟的GDF-5含120个氨基酸残基,通过Smads介导和非Smads介导两种方式诱导目的基因,调控机体的骨骼、软骨等组织的生长发育和修复。近年来,又有研究发现GDF-5能够作用于脂肪来源的间充质干细胞,使其分化成骨、软骨、肌腱。此外,GDF-5在神经系统保护、心脏组织修复等方面的应用前景也越来越受到重视。 Growth differentiation factor-5 （ GDF-5 ） belongs to TGF-I3 superfamily. Mature GDF-5, a 120- amino-acid segment, can regulate the growth and repair of the bones, cartilages, and other tissue by inducing target genc with or without Smads. Recently, studies found the effects of GDF-5 on promoting adipose-derived mesenehymal stem cells into bones, cartilages, and tendons. Moreover, recent findings revealed GDF-5＇ s prospective protection on nerve system and heart tissue healing.
作者 张文婷 罗飞宏
机构地区 复旦大学附属儿科医院内分泌遗传代谢科
出处 《医学综述》 2014年第2期199-202,共4页 Medical Recapitulate
基金 国家自然科学基金(81270929)
关键词 生长分化因子5 软骨 细胞分化 Growth differentiation factor-5 Cartilage Cell differentiation
分类号 R34 [医药卫生—基础医学]
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参考文献37

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同被引文献36

  • 1GUO Xiaodong,DU Jingyuan,ZHENG Qixin,YANG Shuhua,LIU Yong,DUAN Deyu,YI Chengqing.Expression of Transforming Growth Factor β_(1) in Mesenchymal Stem Cells: Potential Utility in Molecular Tissue Engineering for Osteochondral Repair[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2002,22(2):112-115. 被引量：5
  • 2郭晓东,杜靖远,郑启新,刘勇,段德宇,吴永超.Molecular Tissue Engineering: Applications for Modulation of Mesenchymal Stem Cells Proliferation by Transforming Growth Factor β_1 Gene Transfer[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2001,21(4):314-317. 被引量：3
  • 3冷丽,李辉,唐志权,王启贵,王桂华,顾志刚.鸡GDF-5基因外显子1多态性与鸡骨骼发育性状的相关研究[J].畜牧兽医学报,2006,37(3):227-231. 被引量：5
  • 4朱莉丽.兴义矮脚鸡隐性白羽系部分种质特性和杂交利用的研究[D].贵州贵阳:贵州大学,2011.
  • 5Douzgou S, Lehmann K, Mingarelli R, et al. Compound het- erozygosity for GDF5 in Du Pan type chondrodysplasia[J]. Am J Med Genet A, 2008,146(16) :2 116-2 121.
  • 6Miyamoto Y, Mabuchil A, Shi D Q, et al. A functional poly- morphism in the 5"UTR of GDF5 is associated with susceptibil- ity to osteoarthritis[J]. Nature Genetics, 2007,39 (4) : 529- 533.
  • 7Williams F M, Popham M, Hart D J, et al. GDF5 single-nu- cleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women [J]. Arthritis Rheum, 2011,63(3) : 708-712.
  • 8Daans M, Luyten F P, Lories R J. GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subehondral bone exhanges[J]. Ann Rheum Dis, 2011,70 (1) :208-213.
  • 9Gruber HE, Hoelscher GI,, lngram JA, etal. Growth and dif ferentiation factor-5 (GDF-5) in the human intervertebral an nulus cells and its modulation by IL-1β and TNF-a in vitro[J]. Exp Mol Pathol, 2014, 96(2):225-229.
  • 10Feng C, Liu H, Yang Y, et al. Growlh and differentiation fac- tor-5 conlributes to the structural and functional maintenance of the intervertebral disc[J]. Cell Physiol Biochem, 2015, 35 (1):1- 16.

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医学综述
2014年 第2期

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