肥大细胞激活在术后肠梗阻神经免疫机制中的作用

Role of Mast Cells Activation in the Neuroimmuno-mechanism of Postoperative Ileus

术后肠梗阻(POI)是临床常见并发症,其发病机制复杂,一直是外科临床关注的焦点。除已知的神经反射抑制作用外,随着临床与基础研究的深入,炎性反应在本病发生、发展中的重要作用越来越受到重视,而由于肠操作激活肥大细胞成为炎性反应启动的关键,进一步导致巨噬细胞激活及白细胞聚集,加重肠肌层炎症并且与神经机制相互协同作用,从而不利于胃肠运动功能障碍的恢复。该文就肥大细胞在POI神经免疫机制中的效应与促炎过程的研究状况予以综述。

Postoperative ileus （POI） is the common complication after surgical operation with complicated physiopathological mechanisms focused by surgeons. The vital development and progression of inflammatory reaction to POI are more and more concerned about except for inhibitory action of neural reflex. The critical point that exasperating the inflammation of intestinal muscularis and gastroenteric dysmobility is the activation of mast cells triggered by intestinal manipulation cooperated with neural inhibitory by macrophage and leako- cyte aggregation. Here is to make a review of the effect of mast ceils and pminflamatory status in mechanism of POI.